Division of Pulmonary, Critical Care, Sleep and Allergy Research
Introduction
The Division of Pulmonary, Critical Care, Sleep and Allergy members are highly engaged in advancing the science of practice of medicine with diverse areas of expertise including vascular biology, immunology, clinical outcomes and implementation research spread across pulmonary, critical care, sleep and allergy specialties. Our faculty are nationally and internationally recognized as leaders in their respective fields. The specific programs in the Division concentrate in Pulmonary Hypertension, ARDS and Lung Injury, Lung cancer, COPD and Asthma, Sleep Disorders and Nanomedicine and Drug Discovery. We have a very active portfolio of research projects, funded by the National Institutes of Health, VA system, PCORI, AHA, RHA, and various other private foundations or pharmaceutical companies.
Since 2023, the Division has experienced significant growth, with 36 newly awarded grants and over $ 17 million in direct and indirect funding from all active grants, among which 65% is from federal agencies. During this time, its members published original scholarly works supported by more than 26 independently funded investigators specializing in translational pulmonary disease research.
As a result, it has established a strong track record in securing Career Development Awards, with 12 current junior faculty members, obtaining NIH Career Development Awards or equivalent funding over the past 5 years and 2 recently advancing to independent R-level Research Awards at the department.
Scholarly
Fellow Scholarly Activity: National Abstract Presentations
Pulmonary and Critical Care Medicine fellows actively participate in scholarly work spanning basic science, clinical outcomes research, quality improvement, and medical education. The abstracts listed below represent fellow and faculty collaborations presented at the American Thoracic Society (ATS) International Conference and the CHEST Annual Meeting. Other regional or national meetings, or peer-reviewed publications are not listed.
Between 2022 and 2025, fellows contributed to:
- 40 national conference abstracts
- 28 presentations at ATS
- 12 presentations at CHEST
- 25 original research or educational studies
- 15 clinical case reports
These projects span a wide range of topics including pulmonary vascular disease, lung cancer diagnostics, interventional pulmonology, sarcoidosis, critical care education, and health disparities in pulmonary care.
Bolded names indicate PCCM fellows. Residents and other learners are not highlighted, and projects involving residents and faculty members without fellow participation are not included.
Original Research / Education Abstracts
2025
Asghar, M. Fonseca, N. Ravikumar, M. Hammer, V.E. Forth, A.A. Wagh, K. Hogarth, and M. Shafiq. Staged bilateral bronchoscopic lung volume reduction for residual hyperinflation following successful index procedure in pulmonary emphysema: a multicenter study [abstract]. Am J Respir Crit Care Med. 2025;211:A1159.
Asghar, T.M. Ferrer Marrero, T.N. Lloyd, Q. Hosler, and S.S. Yong. An airway curriculum in adult pulmonary and critical care fellowship program: fellows’ satisfaction over four years [abstract]. Am J Respir Crit Care Med. 2025;211:A5617.
J.D. Eccles, C. Ascoli, and G.Y. Park. High-dimensional spectral flow cytometric analysis of allergic airway inflammation [abstract]. Am J Respir Crit Care Med. 2025;211:A3439.
Holbert, J. Gonzales, S.J. Ahn, I. Levitan, C. Ascoli, and D.R. Fraidenburg. In-vitro pathologic flow causes distinct transcriptomic patterns and implicates novel genes in the pathogenesis of sickle cell disease associated pulmonary hypertension [abstract]. Am J Respir Crit Care Med. 2025;211:A7873.
Q.P. Hosler, J. Nudanu, A. Asghar, C. Hawkins, S. Folarin, M. Edison, and T.M. Ferrer Marrero. Relationship between Latin American country’s gross national income and pulmonary and critical care medicine fellows: exposure to video vs direct laryngoscopy in training. Chest. 2025;168(4 suppl):A4497-A4498.
T.N. Lloyd, S. Erp, E. Pacheco, E. Petrucci, T. Ramsaroop, C. Dell, I. Arellano-Nunez, C. Brillante, K. Haas, and M.J. Joo. Race-neutral pulmonary function tests and lung cancer resection candidacy [abstract]. Am J Respir Crit Care Med. 2025;211:A7471.
Nudanu, A. Asghar, C. Hawkins, S. Folarin, M. Edison, and T.M. Ferrer Marrero. Airway management teachings in Latin America [abstract]. Am J Respir Crit Care Med. 2025;211:A5616.
Ramsaroop, K. Holbert, J. Gonzales, S.J. Ahn, I. Levitan, and D.R. Fraidenburg. Hemin and high flow uniquely contribute to endothelial dysfunction in the pathogenesis of pulmonary hypertension in sickle cell disease [abstract]. Am J Respir Crit Care Med. 2025;211:A3009.
N.H. Schwartz, J. Gonzales, K. Holbert, J. Chen, and D.R. Fraidenburg. Characterizing a two-hit murine pulmonary hypertension model of phenylhydrazine-induced hemolysis and hypoxia, echocardiographic findings and markers of endothelial dysfunction [abstract]. Am J Respir Crit Care Med. 2025;211:A6439.
2024
I.A. Acosta Sanchez, K.K. Ortell, M.J. Joo, N. Sweiss, D.R. Fraidenburg, and C. Ascoli. Clinical characteristics of patients with systemic sclerosis and early pulmonary involvement [abstract]. Am J Respir Crit Care Med. 2024;209:A3689.
J.D. Eccles, S.-J. Kim, K.-H. Kim, H.-G. Moon, C. Ascoli, and G.Y. Park. CX3CR1 expression defines a subset of type 2 conventional dendritic cells [abstract]. Am J Respir Crit Care Med. 2024;209:A6683.
Garcia, K.M. Quiñones Cruz, T. Ramsaroop, I. Acosta Sanchez, and T.M. Ferrer Marrero. The impact of a multimodal teaching intervention on resident physicians’ knowledge about the ABCDEF bundle and the barriers to its implementation they could identify [abstract]. Am J Respir Crit Care Med. 2024;209:A1496.
Ogungbile, J. Gonzales, and D.R. Fraidenburg. Hemin-induced necrotic pulmonary artery endothelial dysfunction and capillary leak is regulated by toll-like receptor 4 [abstract]. Am J Respir Crit Care Med. 2024;209:A5142.
R.T. Stringer, K.L. Kovitz, Z. Chen, Z. Xu, M. Strange, K. Abdelhady, M. Lighter, M. Koshy, and M. Pasquinelli. The impact of race, social determinants of health (SDOH), patient choice, and surgical candidacy on interventions for early-stage lung cancer [abstract]. Am J Respir Crit Care Med. 2024;209:A2734.
S.S. Yong, A. Mahgoub, R.T. Stringer, R. Naaman, C.E.R. Green, N.A. Barreras, P. Gupta, A.K. Binder, K.P. Haas, I. Imayama, and T.M. Ferrer Marrero. The longitudinal impact of an airway management curriculum on knowledge acquisition and maintenance in a pulmonary and critical care fellowship program in Chicago [abstract]. Am J Respir Crit Care Med. 2024;209:A1486.
S.S. Yong, C. Kapp, K.L. Kovitz, and K.P. Haas. Assessment of the performance of the first cases of a robotic-assisted bronchoscopy program with long-term follow-up. Chest. 2024;166(4 suppl):A5129.
Elfessi, M.K. Sidhu, N. Sweiss, and I. Rubinstein. Disparate prednisone starting dose in treatment-naive patients with active sarcoidosis in metropolitan Chicago. Chest. 2024;166(4 suppl):A3943.
2023
I.A. Acosta Sanchez, K.K. Ortell, M.J. Joo, N. Sweiss, D.R. Fraidenburg, and C. Ascoli. Clinical characteristics of patients with systemic sclerosis and early pulmonary involvement [abstract]. Am J Respir Crit Care Med. 2023;207:A4821.
Aronson, R. Naaman, K. Haas, K. Kovitz, and C. Kapp. Robotic-assisted bronchoscopy diagnostic yield and complications in a high-risk patient population [abstract]. Am J Respir Crit Care Med. 2023;207:A4466.
Elfessi, A. Mahgoub, B. Williams, E. Tran, G. McGee, and I. Rubinstein. Nocturnal dislodgement of nasal cannula in patients with chronic obstructive pulmonary disease treated with continuous supplemental oxygen: a life-threatening, unmet medical need [abstract]. Am J Respir Crit Care Med. 2023;207:A3326.
M.B. Freedman, Y.J. Kim, L. Ziauddin, J.A. Delisa, A.O. Adegunsoye, S. Alvi, C. Christian, Y.-C. Chung, J.M. Gardner, H.S. Gordon, J.A. Greenberg, L.J. Harnois, B. Jain, R. Karnik, M. Kaul, R. Kaur, L. Keating, N. Khouzam, S.L. Labedz, B. Mokhlesi, S. Pinney, J. Rintz, I. Rubinstein, A. Taylor, S. Tehrani, D.L. Vines, L.B. Gerald, and J.A. Krishnan. Requirements for home oxygen after hospitalization for COVID-19 in 2020 and 2021: results from the U.S. Oxford multicenter retrospective cohort study [abstract]. Am J Respir Crit Care Med. 2023;207:A6322.
Gonzales, W. Chen, Y. Epshtein, C. Humpal, J. Chen, and D.R. Fraidenburg. Murine model of phenylhydrazine-induced chronic hemolysis combined with hypoxia leads to development of severe pulmonary hypertension [abstract]. Am J Respir Crit Care Med. 2023;207:A4660.
Green, C. Argento, J. Thiboutot, M. Pasquinelli, B. Aronson, and C. Kapp. Understanding the social risk factors that avert equitable lung cancer care [abstract]. Am J Respir Crit Care Med. 2023;207:A1092.
2022
Duchnowska, T.M. Ferrer Marrero, M. Reddy, and C.J. Ascoli. Liver abscess development in the postacute COVID-19 phase. Chest. 2022;162(4 suppl):A883.
Egan, M. Kaul, C.J. Ascoli, N. Sweiss, and I. Rubinstein. Paradoxical bronchospasm in a sarcoidosis cohort at a tertiary medical center. Chest. 2022;162(4 suppl):A2222.
Gupta and C.M. Kapp. Not all blebs are created equal. Chest. 2022;162(5):968-969.
Kaul, P. Gupta, and I. Rubinstein. New domiciliary supplemental oxygen therapy after COVID-19 related hospitalization in U.S. military veterans in metropolitan Chicago [abstract]. Am J Respir Crit Care Med. 2022;205:A3167.
Mbae, M. Reddy, M. Kaul, I. Imayama, and T.M. Ferrer Marrero. Preliminary assessment of a formalized airway curriculum in adult pulmonary and critical care fellowship program [abstract]. Am J Respir Crit Care Med. 2022;205:A1532.
Naaman, C. Kapp, K.P. Haas, and K.L. Kovitz. Assessing the diagnostic yield and safety profile of a new robotic-assisted bronchoscopy program in a high-risk patient population. Chest. 2022;162(4 suppl):A2112.
Punal, T.T. Pham, J. Mbae, I.A. Acosta Sanchez, S. Kashyap, M. Colamonici, G. Marrero-Rivera, S. Kalra, M. Panlilio, D. Heyland, and T.M. Ferrer Marrero. Use of a cardiopulmonary resuscitation (CPR) video as an intervention tool to assist ICU trainees-patient code status discussions [abstract]. Am J Respir Crit Care Med. 2022;205:A2882.
Case Report Abstracts
2025
J.D. Eccles, C. Ascoli, and G.Y. Park. Lung involvement with diffuse bronchiolitis pattern in a patient with defective FOXP3 gene [abstract]. Am J Respir Crit Care Med. 2025;211:A3587.
Holzapfel, K. Holbert, and M. Kaul. Blue hope amidst crisis: the rapid course of vasoplegic shock. Chest. 2025;168(4 suppl):A3527-A3528.
Lacavera and C. Vagts. When lungs and light chains collide: cystic lung disease from AL amyloidosis [abstract]. Am J Respir Crit Care Med. 2025;211:A6007.
Nudanu and A.K. Binder. Catastrophic carbon dioxide pulmonary embolism [abstract]. Am J Respir Crit Care Med. 2025;211:A4356.
Noor, S.S. Yong, and C.L. Vagts. The hemorrhagic veil: Kaposi sarcoma in the lungs and its pulmonary manifestations [abstract]. Am J Respir Crit Care Med. 2025;211:A2777.
Ramsaroop, M. Sidhu, and K. Haas. A rare case of urinothorax due to misplaced percutaneous nephrostomy [abstract]. Am J Respir Crit Care Med. 2025;211:A2002.
M.K. Sidhu, P. Kumar, A. Hamdan, and M. Lopata. When immunity backfires: pembrolizumab-induced pneumonitis. Chest. 2025;168(4 suppl):A3096-A3097.
M.K. Sidhu, S. Vedachalam, and K.L. Kovitz. The case of the escaping stent. Chest. 2025;168(4 suppl):A6038-A6039.
2024
Lloyd, A. Mechineni, and A.S. Sahni. It’s just gas—spontaneous pneumorrhachis: alarming images that are benign. Chest. 2024;166(4 suppl):A4009-A4010.
M.K. Sidhu, M. Liu, P. Kumar, A. Hamdan, and T. Yamanaka. Cardiac tamponade masquerading as ST elevation myocardial infarction: a case report. Chest. 2024;166(4 suppl):A590-A591.
S.S. Yong, M. Gallegos, and K.P. Haas. Case of spindle cell carcinoma against the odds. Chest. 2024;166(4 suppl):A4148.
2023
Aronson, I. Acosta Sanchez, and C. Ascoli. An unexpected turn of events: Chryseobacterium indologenes native valve endocarditis [abstract]. Am J Respir Crit Care Med. 2023;207:A5368.
Aronson, I. Acosta Sanchez, and C. Ascoli. When to reassess: a case of toxoplasma-induced pneumonitis in a bone marrow transplant patient [abstract]. Am J Respir Crit Care Med. 2023;207:A6074.
Mahgoub, S.S. Kashyap, and S.S. Sunkara. Unusual cause of bradycardia in the medical intensive care unit. Chest. 2023;164(4 suppl):A393-A394.
2022
Ali, T.T. Pham, and C. Brillante. Intrapleural lytic therapy in the management of pancreatic pleural effusion due to a post-operative complication [abstract]. Am J Respir Crit Care Med. 2022;205:A4177.
Duchnowska, T.M. Ferrer Marrero, M. Reddy, and C.J. Ascoli. Liver abscess development in the postacute COVID-19 phase. Chest. 2022;162(4 suppl):A883.
Research Topics
Research Topics
ARDS / Lung Injury
Patrick Belvitch
Steven Dudek
Jeffrey Jacobson
Sunit Singla
COPD / Asthma
Steven Dudek
Jeffrey Jacobson
Min Joo
Jerry Krishnan
Stephanie LaBedz
Israel Rubinstein
Andrea A. Pappalardo Wlochowicz
Gye Young Park
Lung Cancer
Kevin Kovitz
Mary Pasquinelli
Israel Rubinstein
Nanomedicine Drug Discovery Entrepreneurial Activities
Steven Dudek
Israel Rubinstein
Sunit Singla
Pulmonary Hypertension
Dustin Fraidenburg
Irena Levitan
Sleep Disorders
Bharati Prasad
Vascular Biology
Steven Dudek
Dustin Fraidenburg
Jeffrey Jacobson
Irena Levitan
Sunit Singla
Sarcoidosis / ILD
Christian Ascoli
Steven Dudek
Jeffrey Jacobson
Israel Rubinstein
Christen Vagts
Interventional pulmonary
Peter Boshara
Kevin Haas
Kevin Kovitz
COVID-19, including Post-acute Sequelae of SARS-CoV-2
Israel Rubinstein
Jerry Krishnan
Sunit Singla
Pulmonary Toxicities of E-cigarette Aerosols
Sunit Singla
Research
Basic-Translational Research
Clinical-Outcomes Research
Kevin Haas, MD
Min Joo, MD
Kevin Kovitz, MD, MBA
Jerry A. Krishnan, MD, PhD
Mary Pasquinelli, DNP, FNP-BC
Bharati Prasad, MD
Israel Rubinstein, MD
Health Services Research
Research Awards/Grants
New Grants
Stephanie LaBedz, MD
CCTS KL2 CATS Scholar
Project title: Improving Inhaler Adherence in Underserved Patients with Chronic Obstructive Pulmonary Disease
New important publication from the group of Dr. Gye Young Park
CX3CR1+ Macrophage Facilitates the Resolution of Allergic Lung Inflammation via Interacting CCL26
Am. J. Respir. Crit. Care Med. 2023
The resolution of inflammation not only ceases the inflammatory processes but also requires active processes to restore tissue homeostasis. This is especially true in the cases of inflammation associated with neutrophils and eosinophils because these granulocytes are short-lived cells and undergo apoptotic cell death rapidly. Restoring normal hemostasis won’t be easy after the insults without proper mechanisms to clear dead bodies of tissue-infiltrated granulocytes. The failure of this clearing process could prolong inflammation and lead to chronic inflammatory diseases in humans. Tissue-resident macrophages have been known for this job in neutrophilic conditions because of their high phagocytic capabilities. However, the identity of tissue macrophages for clearing tissue-recruited eosinophils was unknown until we published this paper. Our group, including our lab and collaborating investigators, has been working on searching for the lung macrophages responsible for removing eosinophils in eosinophilic-allergic lung inflammation. Using the human samples from the IRB-approved translational protocol and relevant animal models, we found that the CX3CR1+ macrophage, a subset of lung macrophages, is the one responsible for removing eosinophils in the allergic lungs. Furthermore, applying sophisticated analytic tools such as single cell-RNA sequencing and the SPR method, we discovered the mechanism of how CX3CR1+ macrophages are activated, as shown in the figure. The research highlights the diversity of lung-resident macrophages in terms of their functions and phenotypes. Finally, the discovery could lead to new therapeutic approaches for various inflammatory lung diseases.
Andrea Pappalardo
Andrea A. Pappalardo, MD is an Assistant Professor of Medicine and Pediatrics in the Division of Pulmonary, Critical Care, Sleep and Allergy at the University of Illinois Chicago–UI Health. She has been practicing clinical allergy immunology across the lifespan in a variety of settings including: urban, suburban and community practice for over ten years. She is the Medical Director of the Mobile Care Chicago Asthma and Allergy Program, and the Medical Director of CHECK, a care coordination program for Medicaid recipients in Illinois. Dr. Pappalardo is now shifting her career focus to improving healthcare access through implementation-science based healthcare innovation. Her K12 project is to assess school-based asthma management practices in Chicago Public Schools and pilot a stock inhalers program in select Chicago schools with demonstrated high asthma burden. Health equity is central to Dr. Pappalardo’s work as she focuses on health-related policy implementation.
New Awards
Basic-Translational Research Grants
R01 NHLBI PI: Asrar Malik, MD and Steven Dudek, MD Core Lead
Macrophage Plasticity In Inflammatory Lung Injury – Patient Sampling and Genomics Core Project, 2021-2026