The Breathe Chicago Center (BCC) is a clinical research program within the division of Pulmonary, Critical Care, Sleep and Allergy at the University of Illinois Chicago. Our lab has expertise in late-stage translational research (“healthcare delivery science”), including the methods of stakeholder engagement, systematic reviews, guideline development, clinical effectiveness studies (observational studies and pragmatic clinical trials), implementation science, and the integration of human-centered design in healthcare. We conduct multi-center cohort studies and clinical trials along the discovery to delivery science spectrum to identify, evaluate, and implement new healthcare strategies for patients with asthma, chronic obstructive pulmonary disease (COPD), COVID-19, and post-acute sequelae of SARS-CoV-2.More information about us and the work we do is available at: https://breathechicago.uic.edu/ and https://healthcaredeliverydesign.vcha.uic.edu/.
Roflumilast or Azithromycin to Prevent COPD Exacerbations (RELIANCE) pragmatic clinical trial
Funding: Patient Centered Outcomes Research Institute, ClinicalTrials.gov Identifier: NCT04069312
Brief description: The objective is to compare the real-world effectiveness of chronic roflumilast versus azithromycin therapy in high-risk patients with COPD, with a primary outcome of hospitalization or death. Secondary outcomes are patient-reported measures of physical function, problems with sleep, fatigue, anxiety, and ability to perform usual activities, measured using the NIH-PROMIS instruments. Participants will be followed up for a period of 6 months (minimum) to 36 months (maximum).
CONNECTS Trial Participant Registry (RE-CONNECTS)
Brief description: The objectives of the RE-CONNECTS study are to evaluate whether host-directed anti-thrombo-vasculo-inflammatory interventions for acute COVID-19 influence long term outcomes after SARS-CoV-2 infection; conduct investigations on possible mechanisms by which interventions affect long term outcomes after SARS-CoV-2 infection; and create an engaged community of participants previously enrolled in acute COVID-19 studies that will inform and contribute to the success of future NHLBI programs.
ILLInet RECOVER Hub
Brief description: A Multi-site Observational Study of Post-Acute Sequelae of SARS-CoV-2 Infection in Adults Retrospective and prospective cohort study with nested case-control studies to 1) characterize the incidence and prevalence of sequelae of SARS-CoV-2 infection; 2) characterize the spectrum of clinical symptoms, subclinical organ dysfunction, natural history, and distinct phenotypes identified as sequelae of SARS-CoV-2 infection; 3) define the biological mechanisms underlying pathogenesis of the sequelae of SARS-CoV-2 infection.