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Research Labs

Explore cutting-edge research in the Department of Biochemistry and Molecular Genetics through our state-of-the-art research labs, where innovative investigations and scientific advancements take place.

Ackerman LabTranscriptional mechanisms regulating hematopoietic (myeloid) development and gene expression. Eosinophil effector functions in asthma and other allergic diseases, tissue remodeling, and fibrosis. Biochemistry, cell and structural biology of eosinophil protein mediators of inflammation.
Benevolenskaya LabMechanisms of promotion of differentiation by retinoblastoma protein (pRB), the role of histone demethylases RBP2 and PLU1 in cell fate determination and differentiation in mammalian cells. Global analysis of the transcriptional network regulated by RBP2-related proteins.
Caffrey LabBiochemical and NMR studies are directed at elucidating the structure and mechanisms of viral proteins, development of novel sensors of viruses, antiviral therapeutics
Chronis LabDelineating principles of Stem Cell and iPSC biology and Developmental lineage choice. TF-driven mechanisms that determine cell fate specification during mammalian development, cellular reprogramming, and cancer.
Frolov LabRole of RB tumor suppressor pathway in development and cancer. Single-cell genomics.
Gaponenko LabBiophysical and biochemical characterization of macromolecular interactions with an emphasis on cancer-related proteins, structure based drug discovery and design
Hay LabMechanisms of cell survival, cell cycle control, metabolism, and genesis of cancer. The PI3K/PTEN/AKT/mTOR signaling. The function of Akt isoforms at the cellular and organismal levels.
Jun LabWound repair and regeneration, immune regulation, inflammation, cell signaling
Kuchay LabRegulation of proteostasis at cellular membranes by ubiquitin ligases and a newly identified GGTase 3. Functional involvement in diseases including cancer, cardiovascular disease and metabolic disease.
Lavie LabStructure-based design of novel therapeutic agents by prodrug development and enzyme modifications. X-ray crystallographic structure determination of enzymes involved in prodrug activation.
Merrill LabMammalian stem cell and developmental biology, WNT signaling, Genome Editing.
Nakamura LabRoles of Checkpoint Proteins and Chromatin Modifications in Genome Stability, DNA Repair and Telomere Maintenance.
Raychaudhuri LabRegulation of mammalian cell cycle, cancer biology, transcription factors
Rehman LabCell biology, bioinformatics, Alzheimer’s disease, inflammation and immunity, viral and bacterial infections, metabolism of cancer cells, vascular cells, stem cells and organoids.
Salahudeen LabLung Cancer; Head And Neck Cancer; Squamous Cancers; Neoplasia; Progenitor Cell Plasticity, single cell and spatial transcriptomics
Segev LabFrom Yeast to Human Cells and Disease: 1) Regulation and Coordination of Trafficking Inside Cells: secretion, endocytosis, and autophagy; 2) Neurological Disorders (neurodevelopmental and neurodegeneration)-associated mutations in highly conserved genes
Shikano LabProtein interactions direct the selective sorting of membrane proteins, Regulation of GPCRs, cell signaling
Tyner LabRegulation of epithelial cell differentiation Cell cycle regulation in regenerating tissues.