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Research Grants

Discover the latest achievements and research endeavors with information on recent grants in the Department of Biochemistry and Molecular Genetics at the University of Illinois College of Medicine.

2024

  • Benevolenskaya: Developing inhibitor combinations through identification of drug tolerant cell populations. (PI/NIH R21/24-26)
  • Jun: Coordinated matricellular regulation of intestinal injury repair and regeneration. (PI/NIH R01/24-28)
  • Frolov: Control of cell proliferation and differentiation by growth pathways. (PI/NIH R35/ 24-29)
  • Chakraborty (Rehman lab): Environmental disruption of inflammatory responses in the lung vascular endothelium (AHA’s Second Century Early Faculty Independence Award 24-27)

2023

  • Chronis: Reprogramming Gene Regulatory Networks to a Hematopoietic Stem Cell State. (PI/NIH R01/23-27)
  • Hay: PI3K/PTEN/Akt signaling and the genesis of cancer. (PI/NIH R01/23-28)
  • Lavie: Expanding the efficacy of asparaginase to solid tumors (PI/VA I01/ 23-27)

2022

  • Benevolenskaya: Why Do Some Cancer Cells Persist Despite Treatment for EGFR Lung Cancer? (PI/American Lung Assoc/22-24)
  • Rehman+Chronis: The Lung Endothelium as an Instructive Niche for the Innate Immune System during Vascular Injury. (NIH P01/22-27)
  • Nakamura: Regulation of Telomere Maintenance in Fission Yeast. (PI/NIH R01/22-26)
  • Rehman: iPSC-Derived Vascularized Human Lung Organoids and Interaction Between Lung Endothelial Cells and Alveolar Epithelial Cells. (co-PI/NIH R01/22-26)
  • Rehman: Mechanisms and Treatment of SARS-CoV-2 induced Lung Endothelial Injury. (co-PI/NIH R01/22-26)
  • Rehman: Optogenetic Control of Tumor Initiation and Tumor Progression in vivo. (co-PI/NIH R33/22-25)
  • Segev: Aberrant P-bodies accumulation and clearance in yeast and human cells. (PI/NIH R21/22-23)

2021

  • Hay: Hexokinase 2 and cancer therapy. (PI/NIH R01/21-26)
  • Segev: Coordination of intracellular trafficking pathways by Ypt/Rab GTPases and their GEFs. (PI/NIH MIRA/21-26)
  • Rehman: Endothelial Instruction of Macrophage Fate in Inflammatory Lung Injury. (PL/NIH P01/21-26)
  • Rehman: Fostering Academic Physician-Investigators Treating High Risk Populations. (co-PI/NIH R38/21-25)
  • Merrill+Rehman: RECODE: Synergistic Genetic and Microenvironmental Engineering Platforms For Directed Liver Organoid Differentiation. (co-PIs/NSF/21-25)
  • Rehman: Amplification Mechanisms of Lung Endothelial Inflammation During Acute Lung Injury. (co-PI/NIH R01/21-24)
  • Merrill: Harnessing multiplexed Cas9 genome editing for sequential genetic manipulations and recording activities in cell lineages. (PI/NIH R01/21-24)

2020

  • Kuchay: Proteostasis at cellular membranes. (PI/NIH ESI-MIRA/20-25)

2019

  • Raychaudhuri: Repression function of FoxM1 in metastasis. (PI/NIH R01/19-24)
  • Hay: The Role of Akt in Cell Survival and Cell Growth. (PI/NIH R01/19-24)
  • Frolov: Control of cell proliferation and differentiation by the Retinoblastoma tumor suppressor pathway. (PI/NIH MIRA/19-24)
  • Rehman: Nanoparticle Targeting of Neutrophil Subpopulations in Inflammatory Lung Injury. (co-PI/NIH R01/19-23)
  • Merrill: Development of CLADE: Cell Lineage Annotating DNA Elements. (PI/NIH R21/19-21)