Center for Dissemination and Implementation Science Projects

• Sponsor: Chez Veterans Center Military Service Knowledge Cooperative
• Principal Investigator: Julie Bobitt
• Project Dates: June 1, 2020 – May 31, 2021

Veterans often struggle with disabling conditions, such as chronic pain and PTSD, that tend to worsen as they age. Common treatments for these conditions include the use of opioids and benzodiazepines, yet these medications tend to have unwanted side effects and can even result in addiction. Meanwhile cannabis use in the US has increased significantly over the past decade and a growing number of research studies have highlighted the benefits derived from taking cannabis for medical purposes. Previous studies with older adults have found that individuals are reportedly using cannabis to replace or reduce reliance on opioids and benzodiazepines, however, no research has looked at cannabis relative to opioids and benzodiazepine use in older Veterans. The goal of this study is to develop a deeper understanding of cannabis use in older Veterans who are using it as a substitute or complement for opioids and/or benzodiazepines. Using data collected from older Veterans enrolled in the Illinois Medical Cannabis Program we will identify individual level variables and compare self-reported outcomes associated with using cannabis as a complement or substitute for opioids and/or benzodiazepines. We will also conduct 30 interviews with a sub-set of Veterans who respond to our surveys to discuss cannabis use as a complement or substitute for opioids and/or benzodiazepines.

• Sponsor: Illinois Department of Public Health
• Principal Investigator: Julie Bobitt
• Project Dates: July 1, 2018 – September 30, 2020

Data from the National Survey of Drug Use and Health (NSDUH) showed past-year cannabis use climbed from nearly 3% in 2003 to just over 9% by 2014 in adults age 50-64 and from .2% – 2.1%—a tenfold increase—in adults over age 65. While the number of older adults who use cannabis has been increasing, little is known about the reasons why older adults use cannabis and the outcomes for when they do. We sent surveys to the 16,000+ individuals age 60 and older enrolled in the Illinois Medical Cannabis program to learn about what motivates cannabis use (i.e. chronic pain), describe how cannabis is used, and identify both positive and negative outcomes of cannabis use (i.e. ability to stay active or increased falls risk).

• Sponsor: Midwest Roybal Center for Health Promotion and Translation
• Principal Investigator: Julie Bobitt
• Co Investigators: Laura Payne, Chelsey Byers, Neha Gothe
• Project Dates: June 1, 2021 – May 30, 2022

Research has shown that lifestyle changes such as participating in regular physical activity, staying socially engaged, and managing stress and diet make a positive difference that can delay or reduce cognitive decline. Wits Wellness is a holistic, 12-session (60-minute per session), multi-modal workshop series that offers adults ages 50 and older facilitated, interactive dialogue and activities about healthy behaviors that promote health including, stress management, the importance of physical activity, healthy diet, good sleep, and socialization. We will deliver Wits Wellness to 240 participants in locations throughout Illinois, and conduct a mixed-method evaluation of Wits Wellness using a two-arm randomized controlled trial to determine the feasibility and acceptability of Wits Wellness and examine the preliminary efficacy of Wits Wellness on changes in cognitive function, self-efficacy, socialization, sleep, stress and physical activity levels at 3 and 6 months.

• Sponsor: National Institute of Health
• Principal Investigator: Kelly Bojan

The primary mission of the Adolescent Medicine Trials Network for Human Immunodeficiency Virus (HIV) Interventions (ATN) is to develop and conduct innovative behavioral, community based, translational, therapeutic, microbicide, and vaccine trials in youth residing in the United States who are ages 13-24 years old and at increased likelihood for acquiring HIV or living with HIV (LWHIV), with a focus on the inclusion of minors. The long-term goal of the network is the reduction of new HIV diagnoses among youth and improvements in numbers across the HIV care continuum among adolescents and young adults LWHIV who are medically underserved, of low socioeconomic status, sexual and gender minorities, and/or racial/ethnic minorities, and/or substance-using. Research projects will target highly impacted geographic regions and leverage cross-sector collaborations with community and public health authorities and Federal agencies.

• Sponsor: National Institute of Minority Health and Health Disparities
• Principal Investigator: Natasha Crooks
• Project Dates: September 25, 2023 – May 31, 2028

IMAGE is a family-based HIV/STI intervention engaging Black girls (ages 14-18 years old) and their male caregivers (i.e., biological fathers, stepfathers, grandfathers, brothers, uncles, mentors). IMAGE engages Black male caregivers in STI/HIV prevention for girls in partnership with community-based organizations. Program modules focus on sexual violence and objectification of Black girls and women, relationships, and how to be a positive role model for Black girls. IMAGE is delivered over Saturdays and Sundays at local community-based organizations. The goals of the project include engaging Black families, specifically male caregivers, in protecting Black girls’ sexual and reproductive health, collaborating with community-based organizations in Chicago to deliver IMAGE, supporting the development of healthy Black familial relationships, and facilitating community-based organization uptake and future ownership of IMAGE. Overall, IMAGE is designed to protect Black girls’ sexual development by supporting Black families and communities through increasing their communication, knowledge, and skills in sexual and reproductive health.

• Sponsor: National Institute of Child Health and Human Development (UG3 HD096875/UH3 HD096875)
• Principal Investigators: Linda-Gail Bekker
• Project Dates: September 1, 2018 – August 31, 2023

This project will adapt and evaluate the effectiveness and cost-effectiveness of IMARA, a family-based HIV prevention package for South African adolescent girls and young women and female caregivers. Reducing new HIV and STI infections among South African adolescent girls and young women (AGYW) is global public health priority. South Africa has world’s largest HIV epidemic, and South African adolescent girls and young women acquire HIV at twice the rate of and seroconvert on average 5 – 7 years earlier than male peers. 15-19 year-old females account for over two thirds of new HIV infections in sub-Saharan Africa, but only 15% know their HIV status. HIV mortality is rising among adolescents while decreasing for every other age group. As new infections continue to outpace access to and availability of PrEP and ART, primary prevention remains the most viable strategy to stem new transmissions. South African efforts to prevent HIV transmission in youth focus mostly on individual-level behavior change, but adolescent girls and young women’s persistent HIV disparities are explained by broad social and structural inequities that shape and constrain HIV-risk behaviors. Comprehensive HIV prevention packages that are integrated, synergistic, and tailored to the local epidemiology and cultural context are likely to achieve and sustain maximum reductions in HIV-risk. Female caregivers are an untapped resource in the HIV prevention toolbox and offer a novel opportunity to strengthen AGYW prevention efforts, particularly for uptake of new biomedical technologies like PrEP and HIV testing and counseling. Adolescent girls and young women may also be change agents for female caregivers who want to be positive role models for AGYW and thus, change their own behavior to practice HIV prevention. Establishing the cost- effectiveness of comprehensive HIV prevention packages will inform sustainment over time. This proposal answers a compelling need to reduce incident HIV and STI infections among South African women and AGYW to achieve an AIDS-free generation.

The IMARA program was developed with support (R01 MD006198) from the National Institute of Minority Health and Health Disparities.

• Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
• PI: Sybil Hosek
• Project Dates: 01/03/2024- 10/15/2025

This is a Phase II, randomized, observer-blind, placebo-controlled, multi-site trial of the FDA licensed rMenB+OMV NZ vaccine, Bexsero. The targeted study population is men and women 18-50 years of age who are disproportionately vulnerable to N. gonorrhoeae infection. Approximately 2,200 participants are expected to be enrolled to achieve at least 202 evaluable participants. Data will be collected in an observer-blind manner. Study product recipients and study staff responsible for the evaluation of any study endpoint will be unaware of whether Bexsero or placebo were administered. The duration of the study for participants who are enrolled and randomized will be approximately 16 months. Study participation is expected to be completed in approximately 36 months. The primary objective of the study is to demonstrate efficacy of Bexsero in prevention of urogenital and/or anorectal gonococcal infection.

• Sponsor: National Institute of Allergy and Infectious Diseases (NIAID), Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institute on Drug Abuse (NIDA)
• Principal Investigators: Audrey L. French, MD, Sybil G. Hosek, PhD, Lisa B. Hightow-Weidman, MD, MPH
• Project Dates: March 2023– Ongoing

LITE-2 is an app-based study which has enrolled a diverse cohort of sexually active, racial and ethnically inclusive, gay, bisexual, transgender, and gender diverse adolescents and young adults.​ The project aims to explore the uptake of HIV and STI self-testing among our participants, identify undiagnosed HIV-infections, and monitor HIV incidence over the course of the study.​ LITE-2 will also examine how engagement with our HealthMPowerment (HMP) app impacts the retention and interest in clinical trials throughout the study.​

• Sponsor: National Institute on Drug Abuse (K99 DA047890/R00 DA047890)
• Principal Investigator: Ashley Kendall
• Project Dates: March 1, 2019 – February 28, 2024

Young people placed in the justice system experience important health disparities compared with non-justice-involved peers. Meditation may promote mental and physical health, and can be delivered by smartphone app, reaching youth in their daily lives. In the K99 phase of this study, we partnered with justice-involved youth and a range of community stakeholders–including a Youth Advisory Board, meditation experts, juvenile justice officers, and professional app programmers–to guide the adaptation and implementation of a meditation app for use by youth placed on probation. In the R00 phase, currently underway, we are conducting a longitudinal randomized controlled trial with youth currently placed on probation in the Chicago area to evaluate both clinical and implementation outcomes associated with the adapted meditation app.

• Sponsor: National Center for Complementary and Integrative Health (R34AT012078)
• Principal Investigator: Ashley Kendall
• Project Dates: August 10 2022 – April 30 2025

Juvenile justice officers (JJOs) face high chronic workplace stress. This stress is implicated in a constellation of adverse outcomes underpinned by emotion dysregulation: depression, anxiety, and workplace burnout. Mindfulness-based interventions (MBIs) target emotion dysregulation and show reductions in depression, anxiety, and burnout. Mobile health (mHealth) technology can be harnessed to deliver and tailor MBI content to JJOs during their workdays, presenting a platform that is both scalable on the macro level and responsive to the variability in each JJO’s schedule on the micro level. For the present study, our team is adapting an existing MBI app, Bodhi, according to empirically-supported adaptation targets and conducting a feasibility clinical trial in the Chicago Cook County juvenile justice system.

• Sponsor: National Institute on Minority Health and Health Disparities (R43 MD014113/R44 MD014113)
• Principal Investigators: David Smith and Edward Feil
• Project Dates: September 24, 2019 – May 31, 2024

Youth under age 18 involved in the criminal justice system are disproportionately minorities and affected by substance abuse, mental illness, and HIV/STI. Most young offenders are released on community supervision without the STI, mental health, or substance use screening, diagnosis, and treatment afforded detained youth, despite similar rates of risk behavior. Their long-term trajectory is poor, the costs to society are high, and lasting effects on community well-being and individual employment prospects are profound. Altering this trajectory is a public health priority. SYNC (formerly PHAT Life) is an evidence-based program that meets the need in juvenile justice to address youths’ co-morbid health problems. The next––and perhaps most critical–– step in ensuring that this decade-long line of research produces actual, real-world improvements in the lives of probation youth is to develop a SYNC training strategy that is effective, cost-effective, and sustainable within juvenile justice settings. This private/public collaboration between Oregon Research Behavioral Intervention Strategies and the University of Illinois Chicago will leverage existing resources and competencies to create a commercially viable technology-based training tool for SYNC with great potential for sustainability and cost-effectiveness. Building on SBIR Phase I research, in this Phase II application proposes to use a formative process to refine, enhance and complete the technology-based training tool to include: (a) an interactive multimedia web browser and mobile application, (b) dynamic multimedia presentations and interactive queries, (c) video examples of mock intervention delivery, (d) audio narration along with scripted language, (e) brief quizzes to ensure comprehension and knowledge acquisition, (f) opportunities to “learn more” by clicking on tabs for supplemental information, (g) targeted referrals to appendix materials, (h) games to promote engagement, and (i) other adaptations based on Phase I feedback. The proposed technology-based training tool should be highly sustainable, because it (a) relies on “indigenous” personnel to deliver the intervention, (b) is likely to prove cost-effective since we will utilize a technology that can deliver training at scale, and (c) will improve fidelity by leveraging technology to provide consistent training experiences to para-professionals. We will evaluate the training tool via a 2-arm RCT with 130 individuals who work with justice-involved youth. All trainees will receive the technology-based training tool and half will be randomized to receive supervision prior to real-life delivery. We will evaluate facilitator knowledge and satisfaction, and fidelity to SYNC following real-time intervention delivery. We will assess key implementation outcomes, including cost, feasibility, acceptability and sustainability. The proposed study is highly significant with strong commercialization opportunities for a scalable training solution that supports implementation fidelity and program sustainment addressing a key public health imperative.

• Sponsor: National Insitutes of Health (NIH)
• Principal Investigator: Molly Martin, MD

National Institutes of Health (NIH) Community Engagement Research Alliance Against COVID-19 Disparities (CEAL) research teams are currently working in 21 states to provide trustworthy information through active community engagement and outreach to the people hardest-hit by the COVID-19 pandemic.

The Chicagoland CEAL Program (formerly the Chicagoland COVID Collaborative) is a partnership of academic and community health disparities experts working together to improve COVID-19 vaccination and engagement in quality therapeutic care and trials for low-income Black and Latinx communities in the Chicago area.

• Sponsor: National Insitutes of Health (NIH) / National Institute of Dental and Craniofacial Research (NIDCR)
  Co-Investigator: Molly Martin, MD

Dental cavities are very common in children. More than half (63%) of 3rd-graders in the Chicago area have cavities! If cavities are not treated, they can cause many problems such as pain, severe infections, malnurtition, speech difficulties, poor school performance, cosmetic problems, and lower quality of life.

COordinated Oral Health Promotion (CO-OP) Chicago is working to fix this problem.

CO-OP Chicago is a series of research studies that are trying to find ways to improve oral health for low-income children. One of our studies tested a community health worker model. We are now following families over time to better understand their oral health and social needs.

• Sponsor: Center for Clinical and Translational Sciences (CCTS) at the University of Illinois Chicago
• Principal Investigator: Kate Merrill
• Project Dates: June 1, 2024 through May 31 2025

This study seeks to generate a new mental health session to be integrated into the Floreciendo sexual and reproductive health program for Latina teens and their female caregivers (e.g., mothers, aunts, sisters). We will start by conducting focus group discussions and key informant interviews to inform the design of the new session. We will then use theater testing to obtain real-time feedback from Latina teens and their female caregivers about the program’s acceptability, appropriateness, and feasibility. Finally, we will integrate the new session into the existing Floreciendo curriculum and apply for funding to test the effectiveness of the intervention components of Floreciendo in an optimization trial using the multiphase optimization strategy (MOST) framework. This study is being carried out in partnership with community organizations in the Chicagoland area, with guidance from the Floreciendo Community Advisory Council.

• Sponsor: Eunice Kennedy Shriver National Institute of Child Health & Human Development (K99 HD105490/R00HD105490)
• Principal Investigator: Katherine G. Merrill
• Project Dates: August 11, 2021 – August 31, 2026

Latina adolescents in the U.S. are disproportionately affected by HIV/AIDS/sexually-transmitted infections (STIs) and other adverse consequences of risky sexual behavior. The home environment is recognized to shape adolescents’ health outcomes, but only one Latina mother-daughter sexual health program was identified in the literature. IMARA (Informed, Motivated, Aware, and Responsible Adolescents and Adults) is an evidence-based intervention for African American adolescent girls and their mothers, which is well-suited to be adapted for Latinas. In a randomized controlled trial (RCT) in Chicago, the program reduced the risk of new STIs by 45% compared to the control group among 14-18-year-olds. In this study, we will adapt IMARA to a Latina audience and pilot an optimization trial within community-based organizations (CBOs) in Chicago, using the multiphase optimization strategy (MOST). MOST is a methodological framework for developing an optimal intervention package by assessing the effectiveness of an intervention’s components prior to subjecting the intervention to an RCT. This study focuses on the preparation phase of MOST, using an implementation science approach and drawing on community-based participatory research principles. Findings will form the basis for a fully-powered optimization trial to test intervention component impacts on STI incidence among Latina adolescents. The long-term goal is to generate an efficient, sustainable adapted intervention with potential for scale-up with CBOs serving Latinas.

• Sponsor: National Heart, Lung, and Blood Institute (UG3 HL151302)
• Principal Investigator: Phoenix Matthews
• Role: Co-Investigator and Implementation Scientist
• Project Dates: September 10, 2020 – August 31, 2023

Demonstrating the feasibility, effectiveness, and cost-effectiveness of electronically delivered smoking cessation interventions via patient portals in Federally Qualified Health Care (FQHC) settings has the potential for wide-spread dissemination and significant public health impact. on patient populations with demonstrated high rates of smoking. The specific aims of are to: UG3: Aim 1. Examine the burden of tobacco use and its influence on pulmonary health disparities (lung cancer, COPD, and asthma) in the patient population and the economically disadvantaged and racially segregated catchment areas of Mile Square Health Centers. Aim 2: Evaluate knowledge, attitudes, barriers and facilitators to: smoking cessation, engagement with the tobacco quit line, linkage to the tobacco quit line via a patient health portal and receipt of patient navigation to facilitate access to the tobacco quit line among MSHC patients and health care providers. Aim 3: Evaluate the use of community engagement strategies to increase uptake of the UI Health Patient Portal among low-income patients receiving care at Mile Square Health Center. Aim 4: Test the acceptability, feasibility, and capacity of Mile Square Health to deliver Mi Quit CARE, an evidence-based and multi-level intervention to increase engagement with the quit line via the UI Health Portal. UH3: Aim 1: Determine the effectiveness Mi Quit CARE compared to standard of care in increasing patient engagement with the Illinois tobacco quitline and subsequent smoking cessation outcomes. Aim 2: Evaluate the scalability of Mi Quit CARE to multiple sites within the UI Health FQHC Mile Square clinic network and by translating the intervention to Spanish. Aim 3: Examine the cost effectiveness of Mi Quit CARE on smoking cessation outcomes compared to standard of care among a high risk FQHC population.

• Sponsor: Substance Abuse and Mental Health Services Administration (H79 SP021757)
• Principal Investigator: Geri Donenberg
• Project Dates: September 30, 2016 – September 29, 2022

The purpose of this project is to increase the capacity of the Community Outreach Intervention Projects (COIP) to serve 13-24 year-old African-American (AA) women residing in Chicago’s West, South, and Southeast sides. Through collaboration with partner agencies and input from community members, the activities of this project will build a solid foundation for delivering and sustaining high quality and accessible state-of-the-science HIV prevention and substance abuse services within COIP. IMARA (Informed, Motivated, Aware, and Responsible about AIDS) is a culturally relevant, multi-level, integrated, family-based, HIV and mental health prevention program that simultaneously targets African American women and their daughters. This proposal will increase the availability and accessibility of IMARA and other education and awareness programs, HIV testing and counseling, and evidence-based practices for behavioral and substance use risk reduction, thereby increasing the number of young AA women who are screened, tested, linked to care, and offered brief substance use and sexual risk reduction programs. Increased testing will indicate AA women at high-risk for these health conditions, identify newly discovered positives, and offer on-site HIV primary care. Co-location of behavioral and medical services will create a seamless continuum of primary prevention to active treatment, leading to earlier diagnosis and improved health-related outcomes. The expansion of resources proposed in this application will increase COIP’s capacity to serve 13-24 year old AA women. COIP’s close collaboration with the HIV Community Care Network (HCCN), the Hepatitis C Community Alliance to Test and Treat (HepCCATT), and New Age Services Corporation (NASC) will facilitate referrals for treatment of HIV, viral hepatitis, and serious substance abuse, respectively.

The IMARA program was developed with support (R01 MD006198) from the National Institute of Minority Health and Health Disparities.

• Methods and Translational Science
• Sponsor: National Institutes of Health/Fogarty
• International Center (D43TW010935)
• Principal Investigator: Judith Levy
• Role: Project Co-Director
• Project Dates: April 27, 2018 – January 31, 2023

Unlike many parts of the world where HIV rates are decreasing, Indonesia is experiencing an accelerating AIDS epidemic that affects multiple vulnerable populations across a geographic span of approximately 18,000 inhabited islands. Research and research training is desperately needed to identify and test the best policies and methods to reverse this trend. To help address this challenge, we propose to develop and implement the “UIC/AJCU Training Program in Advanced Research Methods and Translational Science.” The program will entail a collaborative effort between Atma Jaya Catholic University (AJCU) in Jakarta and the School of Public Health, University of Illinois Chicago. The program is designed to build AIDS research capacity at AJCU, train a cadre of highly prepared Indonesian investigators to conduct innovative HIV/AIDS research using advanced research methods and translational science, and contribute to AJCU’s further development toward becoming a Center of Research Excellence for Indonesia. Its underlying goal is to train a next generation of HIV research investigators who can provide the innovative research needed to guide the country’s policies and programming in successfully addressing HIV. The program will meet 3 aims: (1) To train a cadre of highly prepared Indonesian Investigators with the research skills needed to conduct innovative research that will advise HIV social policy, intervention programming, and social/medical services; (2) To further build the institutional HIV research capacity at AJCU and its AIDS Research Center (ARC); and (3) To contribute through research training to AJCU’s development toward becoming a Center of Excellence in HIV research and research training for Indonesia. A mix of AIDS research training and research opportunities will be offered that is designed to produce a next generation of Indonesian HIV/AIDS research investigators. Over the five- year period, we will recruit and train in HIV research: 2 doctoral students in public health who will undertake and complete all requirements for a PhD, 3 post-docs, 2 Informatics Certificate Program trainees, and 4 short- term (3-4 month) trainees. All program trainees will be required to select an area of methodological competence for which they will be required to develop or strengthen their research skills. They also will be required to conduct their studies in Indonesia. Program-sponsored workshops in advanced research methods and translational science held at both universities and also a lecture series at AJCU will inform and/or update faculty/research investigators’ and students’ methodological skills. Seven program strategies will build AIDS research capacity at AJCU and also enhance its development in becoming a Center of Excellence in HIV research and training for the archipelago. The program meets the NIH-identified overarching priority of providing the workforce research training required to conduct High Priority HIV/AIDS or HIV/AIDS-related research. The long-term benefits of the program lie in its impact on improving HIV prevention, treatment, care, and services for Indonesia.

• Sponsor: National Institute of Mental Health (R01MH114937)
• Principal Investigators: Shabnam Javdani, Erin Godfrey
• Role: Co-Investigator
• Project Period: August 23, 2018 – May 31, 2023

In response to the public health threat that suicide poses to American youth in general and incarcerated youth in particular, we propose a multi-year, multi-site, setting-level intervention in the New York City Juvenile Justice system. In partnership with the NYC Administration for Children’s Services (ACS), we will experimentally evaluate an evidence-based staff-level training (S4L) to address youth suicidality during two critical points of contact for juvenile-justice involved youth: placement and post-release Aftercare. S4L combines training in Shield of Care (SOC), an evidence-based model for acute suicide detection training for juvenile justice staff, with evidence-based suicide prevention skill-building training informed by dialectical-behavior therapy for adolescents at risk for suicide ideation, behavior, and non-suicidal self-injury (NSSI). We will compare the effectiveness of S4L to a training as usual control condition (control), and to a condition in which we provide monthly on-site coaching to staff to support the acquisition and implementation of S4L skills (S4L+). The intervention will be implemented as part of ACS’s usual staff-training procedures. The need for intervention is urgent at this time due to recent state-level policy shifts that will increase the number youth in these sites and heighten their suicide risk. S4L and S4L+ will be evaluated using a 3-arm cluster-randomized design with the full population of non-secure placement (NSP)/Aftercare sites (N=30 sites; N=1800 youth, 30% girls). These sites are sole infrastructure for long-term confinement in NYC. NSP/Aftercare sites will be randomized to control (N=10 sites; 600 youth), S4L (N=10 sites; 600 youth), and S4L+ (N=10 sites; 600 youth) conditions. We test the effectiveness of S4L compared to S4L+ and control on improving suicidal behavior, suicidal ideation, and NSSI; mental health outcomes (internalizing, externalizing and substance use); and correlates of suicide/mental health (impulsivity, mood, and coping). In addition, we test the extent to which site-level implementation characteristics (e.g., proportion of staff trained; average amount of detection and prevention activities); site and staff-level structural characteristics (e.g., prior training, burnout); and individual youth characteristics (e.g., demographics; trauma history) moderate S4L and S4L+ effectiveness. Youth outcome data on suicidal behavior, suicidal ideation, NSSI, and mental health problems and their correlates will be tracked longitudinally for 1 year. In response to the FOA, outcomes will be assessed via evidence-based measures that capture dimensional facets of disorder in line with NIH’s common data elements and recommendations by the National Action Alliance for Suicide Prevention. Site-level intervention moderators will be measured by staff survey and administrative data. This project aims to expand the scientific knowledge base on suicide prevention and intervention in high-stakes youth settings and provide empirically-based guidance regarding the feasibility and scalability of staff training and coaching into different juvenile justice systems and jurisdictions. This project leverages an existing collaboration and has the full support of ACS.

• Sponsor: National Institute on Drug Abuse (UG1DA049467)
• Principal Investigator: Niranjan Karnik
• Role: site PI
• Project Dates: June 15, 2019 – February 29, 2024

This project seeks to establish the Great Lakes Node (GLN) of the NIDA-supported Drug Abuse Clinical Trials Network (CTN). This node will draw on an experienced set of investigators who have active collaborations and represent all of the major academic medical centers in the Greater Chicago and Wisconsin areas. The node will serve as a vital Midwestern hub for the CTN and will expand on the success of the CTN approach. In addition, the GLN will bring substantial experience in adolescent/young adult research, seniors/aging research, digital & mobile technologies, opioid misuse, collaborative care/population health, telehealth, and electronic health record and systems-driven interventions and research methodologies. The GLN will support engagement with CTN protocols and also add the following: Aim 1: GLN will identify and recommend substance misuse research and intervention protocols focused on systems-based practice using hospital-based screening, collaborative care, and population approaches. Aim 2: We will establish a digital and computation health core that will leverage our expertise in these domains and serve as a conduit for studies in mHealth, eHealth, artificial intelligence, natural language processing, and telehealth interventions. Aim 3: Our node will bring substantial expertise with youth/adolescent health and seniors/aging that will enable us to recommend studies to the CTN that examine the genesis of substance misuse and the potential for prevention strategies to mitigate these life-course pathways. Aim 4: In alignment with our team’s expertise, we plan to support work on substance and opioid misuse that focuses on health disparities including socioeconomic, geographic, sexual orientation, and gender identity. Aim 5: Leveraging our experience in professional education and practice-based learning, our node will rigorously test the impact of professional education on opioid and substance treatment. We have built on the ECHO model to develop methods to conduct high-quality distance education and supported training that are currently being trialed in Illinois with plans to expand these programs nationally. Aim 6: GLN will expand the pipeline of early investigators interested in substance misuse research. We will align this part of our program with our very successful CTSA-supported programs and build specific subprogramming that supports addiction and substance misuse research, training, and mentorship.

• Sponsor: International Maternal Pediatric And Adolescent Clinical Trials network (IMPAACT) (UM1 AI068632)
• Co-chairs: Geri Donenberg, PhD and Dorothy Dow, MD
• Project Dates: February 1, 2017 – November 30th, 2027

IMPAACT 2016 is a multi-site, two-arm, randomized, controlled study preceded by a feasibility and acceptability pilot to examine if an Indigenous Leader Outreach Model (ILOM) of trauma-informed cognitive behavioral therapy (TI-CBT) intervention demonstrates improved mental health outcomes and ART adherence for youth living with HIV. The study will proceed in two stages over approximately three and one-half years. In Stage, 1 the feasibility and acceptability of the ILOM of TI-CBT program, consisting of 6 two-hour sessions, will be evaluated for 15-19 year-olds living with HIV and their caregivers using the ADAPT-ITT Model. In Stage 2, the efficacy of an ILOM of TI-CBT intervention using a 2-arm randomized controlled trial design will be evaluated for 15-19 year-olds living with HIV and their caregivers. This study will prioritize implementation in countries with high volumes of 15 – 19 year-olds living with HIV, and sites with minimal mental health care infrastructure in order to achieve the biggest impact and deliver the program in areas of greatest need.

Overall support for the International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) was provided by the National Institute of Allergy and Infectious Diseases (NIAID) with co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institute of Mental Health (NIMH), all components of the National Institutes of Health (NIH), under Award Numbers UM1AI068632 (IMPAACT LOC), UM1AI068616 (IMPAACT SDMC) and UM1AI106716 (IMPAACT LC), and by NICHD contract number HHSN275201800001I.