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Nephrology Grants

Research Studies

University of Illinois at Chicago Kidney Precision Medicine Project (KPMP) Chronic Kidney Disease Recruitment Site
The goal of this National Institute of Diabetes, Digestive, and kidney diseases (NIDDK) sponsored study is to ethically obtain high quality research kidney biopsies from patients with chronic kidney disease in order to develop new disease phenotypes and novel treatments for CKD as well as a contemporary state-of-the art atlas of the human kidney.
MPIs; James Lash, MD, Ana C. Ricardo, MD, MPH

Chronic Renal Insufficiency Cohort (CRIC) Study
This NIDDK-sponsored study was established to improve the understanding of chronic kidney disease (CKD) and related cardiovascular illness. The major goals of this multi-center cohort study are to investigate the risk factors for progression of renal disease and cardiovascular disease in patients with mild to moderate chronic kidney disease.
PI: James Lash, MD

Hispanic Chronic Renal Insufficiency Cohort Study
The major goals of this NIDDK-sponsored cohort study are to investigate risk factors for progression of renal disease and cardiovascular disease in Hispanics with chronic kidney disease.
PI: James Lash, MD

Mexican Chronic Renal Insufficiency Cohort Study
The overall objective of this Fogarty International Research Collaboration Award is to recruit and retain a cohort of Mexicans with mild-to-moderate CKD at the Instituto Nacional de Cardiología Ignacio Chávez in Mexico City with the long-term goal of understanding the epidemiology of kidney disease in Mexicans.
PI: James Lash, MD

Sleep Disordered Breathing and Outcomes in Chronic Kidney Disease
This goal of this K23 award is to investigate gender-related disparities in chronic kidney disease progression and cardiovascular outcomes.
PI: Ana C. Ricardo, MD, MPH

University of Illinois at Chicago Hemodialysis Opioid Prescription Effort (HOPE) Clinical Center
The objective of this study is to reduce opioid use and pain control for hemodialysis patients. Results from this research may reduce opioid use and improve pain management practices in dialysis patients.
PI: Michael Fischer, MD, MSPH

Multi-Omics at the Intersections of Environment, Diabetes and Kidney Disease: A Multi-Omics for Health and Disease Study Site
The goal of this study is to establish a diabetes and kidney disease study site comprised of 300 racially and ethnically diverse participants, including 200 with diabetes (half with kidney disease) and 100 healthy controls. Our site will be part of a collaborative initiative with an overall mission to advance the application of integrative multi-omics technologies to study health and disease in ancestrally diverse populations.
PI: Tanika Kelly, PhD, MPIs James Lash, MD, Maria Argos, PhD

Early Life Cardiovascular Disease Risk Factors, Epigenetic Age Acceleration, and Alzheimer's Disease Related Brain Health
The objectives of this study are to evaluate prospective and temporal associations of early life CVD risk factors with epigenetic age acceleration and examine the associations of EAA with 11-year changes in cognitive function and neurobiological substrates.
PI: Tanika Kelly

Clonal Hematopoiesis of Indeterminate Potential (CHIP) in Chronic Kidney Disease Patients
The goal of this study is to evaluate the role of CHIP and its related mechanisms in incident CKD progression and atherosclerotic cardiovascular disease in the setting of CKD setting.
PI: Tanika Kelly

Hispanic Community Health Study/Study of Latinos
The goal of this NHLBI-sponsored prospective population-based cohort study of over 16,000 Hispanic/Latino adults is to examine risk and protective factors for chronic diseases and to quantify morbidity and mortality. This large and diverse study affords the opportunity to study early stages of CKD in this growing population.
PI: Martha Daviglus, MD, PhD, (J. Lash, Co-PI)

Non-Invasive Imaging Biomarkers to Identify a High-risk Chronic Kidney Disease Phenotype
The goal of this K23 Career Development Award is to evaluate the association of kidney microvascular perfusion, as quantified by contrast enhanced ultrasound, with gold standard assessments of kidney function, histopathology, and change in kidney function over time.
PI: Anand Srivastava, MD, MPH

Functional MRI for Enhanced Phenotyping of CKD
The goal of this American Society of Nephrology Carl W. Gottschalk Research Scholar Grant is to incorporate kidney functional magnetic resonance imaging (fMRI)-derived assessments of perfusion, oxygenation, and fibrosis into two Recruitment Sites of the Kidney Precision Medicine Project, which enrolls patients with CKD undergoing a research native kidney biopsy.

U2C/TL1 Chicago KUH FORWARD Research Training Program
This NHLBI-sponsored training program affords opportunities to support nephrology fellows in research focused on health disparities in CKD.
PI: Susan Quaggin MD (James Lash, MD, MPI)

T35 Short-Term Research Training Program in NIDDK Mission Areas
The goal of the proposed SRTP is to provide medical students with a substantive research experience, facilitating the achievement of the long-term objective of increasing the pipeline and diversity of physicians entering the research workforce in NIDDK mission areas.
MPIs James Lash, MD, Waddah Alrefai, MD