Division of Endocrinology, Diabetes and Metabolism Clinical Researchers
Clinical Researchers
Kirstie Danielson, PhD
Kirstie K. Danielson, PhD is an Associate Professor of Endocrinology, Diabetes & Metabolism and Epidemiology & Biostatistics. She received her PhD in Epidemiology from the University of Wisconsin-Madison; and completed postdoctoral training in Endocrinology at the University of Chicago, and Epidemiology at UIC. Dr. Danielson’s expertise as an epidemiologist is in the area of type 1 diabetes (T1D), specifically complications of the disease and therapies for T1D, along with biostatical approaches for large cohort and clinical trial studies. Her previous research has investigated the epidemiology of osteoporosis, cardiovascular disease, and altered reproductive function in patients both living with T1D and after being functionally cured of T1D by islet cell transplantation. And conversely, the impact of bone hormones, vascular function, and estrogen/sex differences on the ability of islet cell transplant to functionally cure T1D. Dr Danielson is internationally recognized for her work in the area of islet cell transplant as a functional cellular cure for T1D, and leads the UIC clinical research team on the first Biologics License Application to the FDA to make islet cell transplant part of standard of care in the U.S. She has been funded by NIH, the CDC, the American Diabetes Association, UIC, foundations, and industry. Dr Danielson has received several research awards and high praise for her teaching and mentoring, directly supervising dozens of students to date in diabetes research at UIC, and is frequently selected for national and international presentations of her work. She developed and teaches one of the most popular Honors College seminars at UIC on Current Perspectives in Diabetes and Treatments.
Publications:
Luu QF, Villareal CJ, Fritschi C, Monson RS, Oberholzer J, Danielson KK. Concerns and hopes of patients with type 1 diabetes prior to islet cell transplantation: a content analysis. J Diabetes Complications 2018; 32: 677-81. PMCID: PMC6015784
Rydzon B, Monson RS, Oberholzer J, Varady KA, Bellin MD, Danielson KK. Long term (4 years) improved insulin sensitivity following islet cell transplant in type 1 diabetes. Diabetes Metab Res Rev 2018; 34: e2972. PMCID: PMC5873303
Madrigal JM, Monson RS, Hatipoglu B, Oberholzer J, Kondos GT, Varady KA, Danielson KK. Coronary artery calcium may stabilize following islet cell transplantation in patients with type 1 diabetes. Clin Transplant 2017; 31: e13059. PMCID: PMC5633499
Hassan LS, Monson RS, Danielson KK. Oestradiol levels may differ between premenopausal women, ages 18-50, with type 1 diabetes and matched controls. Diabetes Metab Res Rev 2017; 33: e2829. PMCID: PMC5124523
Marchese E, Rodeghier C, Monson RS, McCracken B, Shi T, Schrock W, Martellotto J, Oberholzer J, Danielson KK. Enumerating β-cells in whole human islets: sex differences and associations with clinical outcomes after islet transplantation. Diabetes Care 2015; 38: e176-e177. PMCID: PMC4613918
Kujath AS, Quinn L, Elliott ME, LeCaire TJ, Binkley N, Molino AR, Danielson KK. Different health behaviors and clinical factors associated with bone mineral density and bone turnover in premenopausal women with and without type 1 diabetes. Diabetes Metab Res Rev 2015; 31: 421-32. PMCID: PMC4406845
Kujath AS, Quinn L, Elliott ME, Varady KA, LeCaire TJ, Carter CS, Danielson KK. Oxytocin levels are lower in premenopausal women with type 1 diabetes mellitus compared to matched controls. Diabetes Metab Res Rev 2015; 31: 102-12. PMCID: PMC4286520
Yuval Eisenberg, MD
Dr. Yuval Eisenberg area of interest is in neuroendocrinology, specifically pituitary disorders, and in helping to characterize oxytocin derangement in patients who have hypopituitarism. This is the last of the well-recognized pituitary hormones that we do not currently assess clinically and have no regular replacement strategies for now. In addition, I am working with a colleague on an intervention study to assess whether oxytocin is an effective weight loss/diabetes prevention strategy. Finally, I have interest in clinical research related to care of pituitary patients in general. I am conducting clinical research projects looking at practice patterns for postoperative water balance in pituitary patients as well as assessing for surgical volume and outcomes in the chicagoland area.
1) Eisenberg, Y., Murad, S., Casagrande, A. et al. Oxytocin alterations and neurocognitive domains in patients with hypopituitarism, Pituitary (2019). https://doi.org/10.1007/s11102-019-00936-0 .
2) Eisenberg Y, Dugas LR, Akbar A, Reddivari B, Layden BT, Barengolts E. Oxytocin is lower in African American men with diabetes and associates with psycho-social and metabolic health factors.PLoS One. 2018 Jan 4;13(1):e0190301. doi: 10.1371/journal.pone.0190301. eCollection 2018
3) Barengolts E, Green SJ, Eisenberg Y, Akbar A, Reddivari B, Layden BT, Dugas L, Chlipala G., Gut microbiota varies by opioid use, circulating leptin and oxytocin in African American men with diabetes and high burden of chronic disease. PLoS One. 2018 Mar 29;13(3):e0194171. doi: 10.1371/journal.pone.0194171. eCollection 2018.
Sirimon Reutrakul, MD
My research career has been focusing on the interrelationship between sleep, circadian and glucose metabolism. As an endocrinologist, I provide comprehensive clinical are for patients with type 1 and type 2 diabetes, as well as gestational diabetes. This led me to be interested in the relationship between sleep and circadian disturbances to glucose metabolism in disease populations, including type 1 and type 2 diabetes, prediabetes as well as gestational diabetes patients. Interventions to optimize sleep in order to improve glucose metabolism are being conducted.
- A. So-ngern, N. Chirakalwasan, S. Saetung, S. Chanprasertyptin, A. Thakkinstian, S. Reutrakul. Effects of sleep extension on glucose metabolism in chronically sleep-deprived individuals, Journal of Clinical Sleep Medicine, 2019, in press
- H. Nimitphong, A. Mahattanapreut ,La-or Chailurkit, S Saetung, N Siwasaranond, R. Sumritsopak, T. Anothaisintawee, A. Thakkinstian, L.R. Dugas, B.T. Layden, S. Reutrakul. More evening preference is positively associated with systemic inflammation in prediabetes and type 2 diabetes patients, Scientific Reports, 2018, Oct 26;8(1):15882. doi: 10.1038/s41598-018-34045-y
- Saetung, S. Reutrakul, LO Chailurkit, R. Rajatanavin, B. Ongphiphadhanakul, H. Nimitphong. The Association between Daytime Napping Characteristics and Bone Mineral Density in Elderly Thai Women without Osteoporosis. Sci Rep. 2018 Jul 3;8(1):10016. doi: 10.1038/s41598-018-28260-w.
- T. Anothaisintawee, D. Lertrattananon, S. Thammakaison, K.L. Knutson, A. Thakkinstian, S. Reutrakul. The relationship among morningness-eveningness, sleep duration, social jet lag and body mass index in Asian patients with prediabetes”, Frontiers in Endocrinology 2018https://doi.org/10.3389/fendo.2018.00435
- S. Saetung, H. Nimitphong, N Siwasaranond , R. Sumritsopak, P. Jindahra, O. Krairit, A. Thakkinstian, T. Anothaisintawee, S. Reutrakul. The relationship between sleep and cognitive function in patients with prediabetes and type 2 diabetes. Acta Diabetol. 2018 Sep;55(9):917-925. doi: 10.1007/s00592-018-1166-3.
- A. Kijmanawat, P. Panburana, S. Reutrakul, C. Tangshewinsirikul. The effects of probiotic supplements on insulin resistance in gestational diabetes mellitus: a double-blind randomized controlled trial, J Diabetes Invest 2018, May 20. doi: 10.1111/jdi.12863
- Nimitphong, N. Siwasaranond, S. Saetung, A. Thakkinstian, B. Ongphiphadhanakul, S. Reutrakul . The relationship among breakfast time, morningness-eveningness preference and body mass index in Type 2 diabetes. Diabet Med. 2018 35(7):964-971
- Reutrakul, E. Van Cauter. Sleep influences on obesity, insulin resistance, and risk of type 2 diabetes, 2018 Metabolism,Mar 3. pii: S0026-0495(18)30063-5. doi: 10.1016/j.metabol.2018.02.010
- S. Amnakkittikul, N. Chirakalwasan, E. Wanitcharoenkul, S. Charoensri, S. Saetung, S. Chanprasertyothin, L. Chailurkit, P. Panburana, S. Bumrungphuet, S. Reutrakul
Postpartum Resolution of Obstructive Sleep Apnea in Women with Gestational Diabetes and the Relationship with Glucose Metabolism, Acta Diabetologica, 2018; 55(7):751-754. - N. Siwasaranond, H. Nimitphong, A. Manodpitipong, S. Saetung, N. Chirakalwasan, A. Thakkinstian, S Reutrakul. The Relationship between Diabetes-Related Complications and Obstructive Sleep Apnea in Type 2 Diabetes, Journal of Diabetes Research, 2018 Mar 7;9269170
- Lappharat, N. Taneepanichskul, S. Reutrakul, N. Chirakalwasan. Effects of Bedroom Environmental Conditions On The Severity of Obstructive Sleep Apnea, J of Clin Sleep Medicine, 2018;14(4):565-573
- Chirakalwasan , S. Amnakkittikul, E. Wanitcharoenkul, S. Charoensri, S. Saetung, S. Chanprasertyothin, L. Chailurkit, P. Panburana, S. Bumrungphuet, A. Thakkinstian, S. Reutrakul. Continuous Positive Airway Pressure Therapy in Gestational Diabetes with Obstructive Sleep Apnea: a Randomized Controlled Trial, J of Clin Sleep Medicine, 2018, 14(3): 327-336