Center for Advanced Resuscitation Medicine (CARM)
Center for Advanced Resuscitation Medicine Heading link
The Center for Advanced Resuscitation Medicine (CARM) at University of Illinois Chicago was founded in 2011. It brought together scientists and clinicians to advance the understanding of sudden cardiac arrest, hemorrhagic shock, and hypertension from molecular, translational, and clinical perspectives. The mission of CARM is to integrate cutting-edge research, education, and clinical leadership to facilitate the translation of new discoveries into improved patient care and community health, and reduced racial/ethnic disparities.
Research Interests Heading link
Research Interests
- Sudden cardiac arrest
- Hemorrhagic shock
- Hypotension
- Community Medicine
- Therapeutic hypothermia
- Ischemia reperfusion injury
Research Interests
- Reactive oxygen species
- Mitochondria
- Cardiomyocyte biology
- Metabolism
- Complementary medicine
- Ultra sound
Funding Heading link
- NIH R01: Novel Therapies for CPR
- UIC Chancellor’s Innovation Award: Novel TAT – peptide Improves Sudden Cardiac Arrest Survival-
- Medtronic Foundation: Illinois Heart Rescue Project: Improving cardiac arrest survival among vulnerable populations of Illinois
- Research Triangle Institute and Medtronic Philanthropy: India heart Rescue Project: Improving STEMI and cardiac arrest survival among at-risk populations of India
- NIH R01: Novel Peptides for Resuscitation
- Chicago Biomedical Consortium: Novel PHLPP Peptide for Asystole/PEA Resuscitation
Representative Publications Heading link
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Representative Publications
- Reperfusion injury on cardiac myocytes after simulated ischemia. Vanden Hoek TL, Shao Z, Li C, Zak R, Schumacker PT, Becker LB. Am J Physiol. 1996 Apr;270(4 Pt 2):H1334-41.PMID:8967373.
- Mitochondrial electron transport can become a significant source of oxidative injury in cardiomyocytes. Vanden Hoek TL, Shao Z, Li C, Schumacker PT, Becker J Mol Cell Cardiol. 1997 Sep;29(9):2441-50. PMID: 9299367.
- Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes. Vanden Hoek TL, Becker LB, Shao Z, Li C, Schumacker PT. J Biol Chem. 1998 Jul 17;273(29):18092-8. PMID:9660766.
- Mitochondrial Transporter Responsiveness and Metabolic Flux Homeostasis in Postischemic Hearts. O’Donnell JM, LT White, and ED Lewandowski. Amer. J. Physiol. 1999 Sep;277(3 Pt 2):H866-H873. PMID:10484405.
- Extract from Scutellaria baicalensis Georgi attenuates oxidant stress in cardiomyocytes. Shao ZH, Li CQ, Vanden Hoek TL, Becker LB, Schumacker PT, Wu JA, Attele AS, Yuan CS. J Mol Cell Cardiol. 1999 Oct;31(10):1885-95. PMID:10525426.
- Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion. Vanden Hoek T, Becker LB, Shao ZH, Li CQ, Schumacker PT. Circ Res. 2000 Mar 17;86(5):541-8. PMID:10720416.
- Reperfusion, not simulated ischemia, initiates intrinsic apoptosis injury in chick cardiomyocytes. Vanden Hoek TL, Qin Y, Wojcik K, Li CQ, Shao ZH, Anderson T, Becker LB, Hamann KJ. Am J Physiol Heart Circ Physiol. 2003 Jan;284(1):H141-50. Epub 2002 Oct 10. PMID:12388298.
- Altering CO2 during reperfusion of ischemic cardiomyocytes modifies mitochondrial oxidant injury.Lavani R, Chang WT, Anderson T, Shao ZH, Wojcik KR, Li CQ, Pietrowski R, Beiser DG, Idris AH, Hamann KJ, Becker LB, Vanden Hoek TL. Crit Care Med. 2007 Jul;35(7):1709-16. PMID:17522572
- SERCA1 Expression enhances the metabolic efficiency of improved contractility in post ischemic hearts. O’Donnell JM, Pound K., Xu X, and Lewandowski ED. J Mol Cell Cardio. 2009 Nov;47(5):614-21. PMID: 19744494.
- Therapeutic hypothermia cardioprotection in murine hemorrhagic shock/resuscitation differentially affects p38α/p38γ, Akt, and HspB1. Li J, Beiser DG, Wang H, Das A, Berdyshev E, Li J, Leff AR, Stern SA, Vanden Hoek J Trauma. 2011 Nov;71(5):1262-70. PMID:22071928.
- Baicalein protects cardiomyocytes against mitochondrial oxidant injury associated with JNK inhibition and mitochondrial Akt activation. Huang HH, Shao ZH, Li CQ, Vanden Hoek TL, Li Am J Chin Med. 2014;42(1):79-94. doi: 10.1142/S0192415X14500050. PMID:24467536.
- TAT-protein blockade during ischemia/reperfusion reveals critical role for p85 PI3K-PTEN interaction in cardiomyocyte injury. Zhu X, Shao ZH, Li C, Li J, Zhong Q, Learoyd J, Meliton A, Meliton L, Leff AR, Vanden Hoek PLoS One. 2014 Apr 21;9(4):e95622. PMID:24752319.
- Lipid emulsion rapidly restores contractility in stunned mouse cardiomyocytes: a comparison with therapeutic hypothermia. Li J, Fettiplace M, Chen SJ, Steinhorn B, Shao Z, Zhu X, Li C, Harty S, Weinberg G, Vanden Hoek Crit Care Med. 2014 Dec;42(12):e734-40. PMID:25402294.
- A novel pharmacological strategy by PTEN inhibition for improving metabolic resuscitation and survival after mouse cardiac arrest. Li J, Wang H, Zhong Q, Zhu X, Chen SJ, Qian Y, Costakis J, Bunney G, Beiser DG, Leff AR, Lewandowski ED, ÓDonnell JM, Vanden Hoek Am J Physiol Heart Circ Physiol. 2015 Jun 1;308(11):H1414-22. PMID:25795713.
- Save-a-life at the ballpark: 10-min spectator training achieves proficiency in cardiac arrest Del Rios M, Aldeen A, Campbell T, Demertsidis E, Heinert S, Sinchi J, Vanden Hoek T. Resuscitation. 2015 Feb;87:21-5. PMID:25447034. PMID:25447304.
- Correlation between Subclinical Heart Disease and Cardiovascular Risk Profiles in an Urban Emergency Department Population with Elevated Blood Pressures: A Pilot Study. Prendergast HM, Colla J, Patel N, Del Rios M, Marcucci J, Scholz R, Ngwang P, Cappitelli K, Daviglus M, Dudley S. J Emerg Med. 2015 Jun;48(6):756-61. PMID:25802165.
- Baicalein preventive treatment confers optimal cardioprotection by PTEN/Akt/NO activation. Li J, Chang WT, Li CQ, Lee, CP, Huang HH, Hsu CW, Chen WJ, Zhu, XD, Wang CZ, Vanden Hoek T, Shao, ZH. J. of Chin. Med. 2017 Aug 45(5):987-1001. PMID:28760044.
- A hypertension emergency department intervention aimed at decreasing disparities: Design of a randomized clinical trial. Prendergast HM, Del Rios M, Petzel-Gimbar R, Garside D, Heinert S, Escobar-Schulz S, Kotini-Shah P, Brown M, Chen J, Colla J, Fitzgibbon M, Durazo-Arvizu RA, Daviglus M. Contemp Clin Trials. 2018 Jan;64:1-7. PMID:29128648.
- Baicalein Rescues Delayed Cooling via Preservation of Akt Activation and Akt-Mediated Phospholamban Phosphorylation. Shao ZH, Chen SJ, Zhu X, Lee C, Huang HH, Meliton A, Li CQ, Vanden Hoek TL, Li J. Int J Mol Sci. 2018 Mar 24;19(4). PMID:29587364.
- Implementing a STEMI System of Care in Urban Bangalore: Rationale and Study Design for Heart Rescue India. Ramesh A, LaBresh K, Begeman R, Bobrow B, Campbell T, Chaudhury N, Edison M, Erickson T, Manning J, Prabhakar B, Kotini-Shah P, Shetty N, Williams P, VandenHoek T. Contemp Clin Trials Commun. 2018 In Press.
