Strategies to Innovate EmeRgENcy Care Clinical Trials (SIREN) Network

The Strategies to Innovate EmeRgENcy Care Clinical Trials (SIREN) Network is jointly funded by NHLBI, NINDS, DOD, and NCATS. More emergency care research is needed to improve outcomes in leading causes of death and disability, including heart attack, stroke, cardiac arrest and trauma. While we know that early treatment in many of these conditions can significantly improve outcomes, research studies of possibly better or new treatments can be difficult to implement in the emergency department setting. The SIREN program creates a single network in the United States for high quality emergency care research capable of answering such important questions. Participating hospitals and emergency medical services within this network will study patients with neurologic (e.g. stroke, seizure), cardiac (heart attack, congestive heart failure, cardiac arrest), traumatic (car accident, gunshot wounds), pulmonary (asthma, emphysema) and hematologic (sickle cell crisis, acute anemia) emergencies. The SIREN program builds upon both the Resuscitation Outcomes Consortium (ROC) and the Neurologic Emergencies Treatment Trials (NETT) as remarkably successful multiple large-scale clinical trial networks that have helped improve both emergency research processes and care. Trials conducted through these research networks have greater efficiency than similar trials outside these networks. Given this success, the SIREN program seeks to continue support of a network infrastructure that will efficiently conduct at least four randomized, clinical endpoint trials related to emergency medicine over a five-year period.

The purpose of the SIREN Network is to:

  • Provide a robust and readily accessible infrastructure for rapid implementation and high quality performance of clinical trials in patients with neurologic, cardiac, respiratory, and hematologic, and trauma emergency events
  • Advance emergency medicine by efficiently enabling performance of rigorous comparative effectiveness studies and assessments of novel therapeutic interventions

The University of Illinois at Chicago is part of the Medical College of Wisconsin Hub.

UIC Adult Expansion Sites Include:

  • Rush University Medical Center
  • John H. Stroger Cook County Hospital
  • Sinai Health Hospital
  • Advocate Lutheran General Hospital
  • Advocate Christ Hospital
  • Advocate Illinois Masonic Hospital
  • OSF Saint Francis Hospital


Marina Del Rios, MD

Sandra Escobar-Schulz