Heng-Fu (Henry) Bu, DVM, PhD
Research Associate Professor
Department of Pediatrics
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About
Dr. Bu's research employs advanced molecular techniques and animal models to investigate the pathophysiology of tissue inflammation and regeneration, along with therapeutic approaches for various human diseases affecting digestive tissues and organs. Dr. Bu encompasses three primary areas:
- Examining the impact of sepsis on intestinal epithelial cell homeostasis, leading to the identification of protective factors such as lysozyme-modified probiotic components (LZMPC) and milk fat globule-epidermal growth factor 8 (MFG-E8).
- Investigating acute colitis in murine models of inflammatory bowel disease, which has resulted in the discovery of inflammation-attenuating factors, including MFG-E8, silent information regulator-sirtuin 6 (Sit6), and H19 long non-coding RNA.
- Utilizing a novel triple-transgenic mouse model (3xTg-iHAP) with inducible hepatocyte-specific apoptosis, revealing a correlation between liver wound healing and increased MFG-E8 expression in hepatocytes. Ongoing research focuses on elucidating the specific role of MFG-E8 in hepatocytes using MFG-E8 knockout 3xTg-iHAP animals.