Rotation Projects

– Characterizing mechanism of binding and action of the hybrid ribosome-targeting antibiotics: characterization of resistant mutants, in vitro translation, binding studies.

– Exploring mechanisms of action of translation factors in bacteria: constructing tagged translation factors for genome-wide ribosome profiling analysis: gene cloning, protein characterization, ribosome profiling

– Unraveling the mechanism of action of antibacterial trans-translation inhibitor: designing the assays for testing the activity of a putative inhibitor of the ribosome rescue system in bacteria: cloning, expressing and testing activity of the ABC-F macrolide resistance protein.

– Generating the tunable library for the selection of the antibacterial peptides with improved activity.

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