In REACH Lab we strive to better understand the role of adipose tissue secretions in the initiation and progression of human diseases with the ultimate goal of identifying novel therapeutic targets and preventive strategies for obesity-related diseases. We seek to accomplish this goal via conducting interdisciplinary research with translational potential in obesity and related morbidities including diabetes, cardiovascular diseases, and hormonedependent malignancies. A major research focus in our lab is endothelial cell dysfunction as an underlying mechanism in the pathogenesis of a wide range of obesity-associated diseases, including peripheral vascular disease, stroke, heart disease, diabetes, insulin resistance, and tumor invasion and metastasis. Our present research focuses on unraveling multiple molecular and epigenetic processes to better understand the multidimensional crosstalk between adipocytes and endothelial cells.
REACH Laboratory PDF