Ocular Cell Biology Laboratory

Beatrice Y.J.T. Yue, PhD, Director
Thanis A. Field Professor of Ophthalmology and Visual Sciences

Personnel

Beatrice Yue, PhD

Xiang Shen, Research Specialist

Selected Publications:

1. Shen X, Ying H and Yue BYJT: Wnt activation by wild type and mutant myocilin in cultured human trabecular meshwork cells. PLoS One 7:e44902, 2012.
2. Ying H, Shen X and Yue BYJT: Establishment of inducible wild type and mutant myocilin-GFP-expressing RGC5 cell lines. PLoS One 7:e47307, 2012.
3. Ying H and Yue BYJT: Cellular and molecular biology of optineurin. Int Rev Cell Mol Biol 294:223-258, 2012.
4. Czugala M, Karolak JA, Nowak DM, Polakowski P, Pitarque J, Molinari A, Rydzanicz M, Bejjani BA, Yue BYJT, Szaflik JP, and Gajecka M: Novel mutation and three other sequence variants segregating with phenotype at keratoconus 13q32 susceptibility locus. Eur J Hum Genet 20:389-397, 2012.
5. Shen X, Ying H, Qiu Y, Shyam R, Park J, Chi Z, Iwata T and Yue BYJT: Cellular processing of optineurin in neuronal cells. J Biol Chem 286:3618-3629, 2011.
6. Koga T, Shen X, Park J, Qiu Y, Park BC, Shyam R and Yue BYJT: Effects of myocilin and optineurin, two glaucoma genes on neurite outgrowth. Am J Pathol 176:343-352, 2010.
7. Ying H, Shen X, Park BC and Yue BYJT: Posttranslational modification, localization and protein protein interactions of optineurin. PLoS One 5:e9168, 2010.
8. Park BC, Ying H, Shen X, Park JS, Qiu Y, Shyam R and Yue BYJT: Impairment of protein trafficking upon overexpression and mutation of optineurin. PLos One 5:e11547, 2010.
9. Shen X, Koga T, Park BC, SundarRaj N and Yue BYJT: Rho GTPase and cAMP/PKA signaling mediates myocilin induced alterations in cultured human trabecular meshwork cells. J Biol Chem 283:603-612, 2008.
10. Sakai H, Shen X, Koga T, Park BC, Noskina Y, Tibudan M and Yue BYJT:  Mitochondrial association of myocilin in human trabecular meshwork cells. J Cell Physiol 213:775-784, 2007.