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Photo of Patil, Chandrashekhar D.

Chandrashekhar D. Patil, PhD

Research Assistant Professor

Department of Ophthalmology and Visual Sciences


Dr. Patil is a Research Assistant Professor working within the laboratory of Dr. Deepak Shukla. Dr. Patil's research is centered on investigating herpesvirus infection models, both in vitro and in vivo, with a particular focus on elucidating the role of optineurin in regulating viral infections. He employs cutting-edge Optn KD/KO tools, encompassing human-origin neurons, human corneal epithelial cells, immune cells (THP1), HeLa cells, as well as primary cell lines from mice (BMDMs, MEFS, Neuronal stem cells). Dr. Patil is dedicated to addressing fundamental inquiries concerning the intrinsic and innate immune host defense mechanisms modulated by OPTN in response to HSV infection. 

Selected Publications

  • Patil CD, Shukla D. OPTN (optineurin)-mediated selective autophagy prevents neurodegeneration due to herpesvirus infection. Autophagy. 2022 Feb 16:1-2. PMID: 35167411 DOI: 10.1080/15548627.2022.2037223 
  • Ames J, Yadavalli T, Suryawanshi R, Hopkins J, Agelidis A, Patil C, Fredericks B, Tseng H, Valyi-Nagy T, Shukla D. OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection. Nat Commun. 2021 Sep 13;12(1):5401. PMID: 34518549 DOI: 10.1038/s41467-021-25642-z 
  • Patil CD, Suryawanshi RK, Kapoor D, Shukla D. Postinfection Metabolic Reprogramming of the Murine Trigeminal Ganglion Limits Herpes Simplex Virus-1 Replication. mBio. 2022 Oct 26;13(5):e0219422. doi: 10.1128/mbio.02194-22. Epub 2022 Aug 31. PMID: 36043789; PMCID: PMC9600155.
  • Ames J, Yadavalli T, Patil C, et al. OPTN limits herpes stromal keratitis severity and demyelination through negative regulation of IL-17 and hyperinflammatory T-cell response. bioRxiv; 2021. DOI: 10.1101/2021.11.29.470418.


PhD: North Maharashtra University
Postdoctoral Fellowship: Université de Perpignan, UPVD, France
Postdoctoral Fellowship in Biotechnology Engineering: Ben Gurion University of the Negev, Beersheba, Israel