| PI | Funder | Title | Description |
| Chen, Tianji | American Lung Association | Role of PDLIM5 in the Pathogenesis of Pulmonary Hypertension | PDZ and LIM domain 5 (PDLIM5), also known as enigma homolog (ENH), is a ~64kDa cytoplasmic protein consisting of an N-terminal PDZ and three consecutive C-terminal LIM domains. It is one member of the PDZ-LIM protein family that is comprised of evolutionarily conserved proteins containing a PDZ domain and at least one LIM domain. The PDZ domain interacts with actin-binding proteins such as α-actinin and localizes the PDZ-LIM proteins and other complexed proteins to filamentous actin, while the LIM domains bind to diverse partners like signaling molecule PKC or transcriptional factor Id2 etc. Thus, the PDZ-LIM proteins function by sequestering nuclear factors in the cytoplasm. Combining two functional domains in one protein, it is not surprising that PDZ-LIM proteins have diverse functions and play important roles in development and maintaining physiological homeostasis. However, the role of PDZ-LIM proteins in the pathogenesis of pulmonary hypertension (PH) is unknown. We found that PDLIM5 expression was upregulated in pulmonary arterial smooth muscle cells (PASMC) isolated from associated pulmonary arterial hypertension (APAH) patients, as well as that of mice or rats with established PH. Overexpression of PDLIM5 inhibited hypoxia-induced PH in mice in vivo, while smooth muscle cell (SMC)-specific knockout of PDLIM5 in mice enhanced hypoxia-induced pulmonary arterial remodeling. Based on these findings, we hypothesize that PDLIM5 expression in PASMC is induced as an adaptive response to the development of PH, so that it can function as an internal brake to inhibit the further progression of disease. To test our hypothesis, we will investigate the downstream mechanisms by which PDLIM5 inhibits the progression of PH, as well as how it is regulated during the disease development. The findings will provide novel insights into PH, which may result in the design of novel therapeutic strategies for the treatment of the disease. |
| Chen, Tianji | Gilead | A protective role of miR-212-5p in pulmonary hypertension | Same as previous |
| Raj, Usha and Zhou, Guofei | NIH: NHLBI | Role of MicroRNA-17-92 and PDLIM5 Signaling in Pulmonary Arterial Hypertension | This project aims to elucidate the molecular mechanisms underlying the microRNA-17~92/PDLIM5 signaling-mediated pulmonary artery smooth muscle cell phenotype change and its functional impact in the genesis of pulmonary hypertension. We are continuing to investigate the role of PDLIM5 in the metabolic shift and to carry out a PDLIM5-targeted drug development process for the treatment of pulmonary hypertension. https://projectreporter.nih.gov/project_info_description.cfm?aid=9261587&icde=36701786 |
| Reddy, Sekhar | NIH | Fra-1/Nrf2 Balance Signaling and Resolution of Inflammatory Lung Injury | Chronic, non-healing wounds of the skin are serious medical complications that affect over 6.5 million Americans, especially older adults. These wounds include pressure sores, diabetic foot ulcers and venous ulcers. There are numerous surgical and dressing treatments for these wounds, but because there are over 70,000 lower-limb amputations each year arising from these wounds, it is clear that new treatments are needed. Strikingly, there are almost no pharmaceutical therapies to accelerate healing of chronic wounds. A major contributor to chronic wounds is a prolonged inflammatory state, and reducing inflammation may be a way to accelerate healing of chronic wounds. Unfortunately, many commonly used anti-inflammatory drugs hinder chronic wound healing; thus, new ways of reducing inflammation are needed. An essential factor in wound healing and an important regulator of inflammation is Nrf2, a transcription factor that induces many cytoprotective and antioxidant genes. As seen in other inflammatory disorders, activating Nrf2 could be a useful therapeutic strategy to treat chronic skin wounds. There are a number of covalent Nrf2 activators, but they are not selective for Nrf2, which is problematic because some of the off-target effects of these molecules are at proteins that hinder chronic wound healing. Thus, pharmacologic activation of Nrf2 with non-covalent small molecules will accelerate wound healing, which could lead to new therapeutics to treat chronic wounds. Our lab, in collaboration with Drs. DiPietro and Reddy labs at UIC, are using metabolism and pharmacokinetics studies, to develop high-affinity, metabolically stable, in vivo probes of Nrf2 activation for chronic wounds. These experiments are significant because they will develop novel in vivo probes of non-covalent Nrf2 activation, and they are innovative because they will open up new therapeutic strategies to treat chronic wounds. https://moorelab.publish.uic.edu/research/ |
| Reddy, Sekhar | NIH | Role of Nrf2 in Alveolar Epithelial Cell Regeneration During Lung Repair | Same as previous |
| Reddy, Sekhar | NIH | Fra-1 – A20 Signaling and Resolution of Pneumonia-Induced Sepsis | Same as previous |
| Rivers, Angela | Acetylon Pharmaceuticals Inc | Effective HUDEP Inhibitors on HbF | |
| Rivers, Angela | NIH: NHLBI | Mitophagy as Potential Target in Sickle Cell Disease | https://projectreporter.nih.gov/project_info_description.cfm?aid=9350389&icde=38449027&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC&pball= |
| Rivers, Angela | M.R. Bauer Foundation | Sickle Cell Transition Program | Individuals with sickle cell disease suffer from chronic hemolytic anemia, vaso-occlusive pain crises, multisystem organ damage, and a shortened lifespan. The disease is caused by a mutation of the β-globin gene; this mutation allows for the polymerization of the sickle hemoglobin (HbS) when deoxygenated. Many patients are lost to healthcare follow-up during the transition from pediatric to adult care. The peer patient advocate is an individual with Sickle Cell Disease who serves as a community health worker. The peer patient advocate builds relationships and connections with patients, families, and the sickle cell community. The peer patient advocate will be closely connected to patients and families and will participate in the following areas of care: 1) group care sessions as facilitator 2) Sickle cell transition fair coordination 3) Visiting pediatric patients in hospital and clinic. The advocate will assist with the transition of the medical, social, and professional lives of adolescents living with Sickle Cell disease from pediatric to adult care. |
| PI | Funder | Title | Description | ||||
| Boucher-Berry, Claudia | Univ of South FL (Prime sponsor: NIH and others) | Type 1 Diabetes TrialNet Study | https://www.trialnet.org/ | ||||
| Boucher-Berry, Claudia | Eli Lilly & Co | A Randomized, Double-Blinded Study with an Open-Label Extension Comparing the Effect of Once-Weekly Dulaglutide with Placebo in Pediatric Patients with Type 2 Diabetes Mellitus (AWARD-PEDS) H9X-MC-GBG | |||||
| Choi, Daniel | Coleman Foundation | The Coleman Supportive Oncology Collaborative for Children with Cancer, Cycle 2 | |||||
| Boucher-Berry, Claudia | Lurie Children’s (Prime sponsor: NIH) | Effectiveness of an e-health intervention | https://projectreporter.nih.gov/project_info_description.cfm?aid=9309224&icde=38450213&ddparam=&ddvalue=&ddsub=&cr=6&csb=default&cs=ASC&pball= | ||||
| Hayani, Karen | Harvard School of Public Health (Prime sponsor: NIH NICHD) | Pediatric HIV/AIDS Cohort Study (PHACS) Data and Operations Center (DOC): Smart | |||||
| Hoganson, George | IL Dept of Public Health (IDPH) | Regionalized Care in the Treatment of Biochemical Genetic Diseases Detected from State of IL Newborn | |||||
| Hsu, Lewis | Pfizer Inc | An Open-Label Study to Evaluate the Safety and Pharmacokinetics of PF-06412528 in Children 7-17 Years for the Treatment of Moderate-to-Severe Chronic Pain B4541006 EMBEDA | |||||
| Hsu, Lewis | Pfizer Inc | An Open-Label Study to Evaluate the Pharmacokinetics and Safety of ALO-02 Extended -Release Capsules in Children and Adolescents 7-17 Years of Age Who Require Opioid Analgesia B4531015 AL-02 | |||||
| Hsu, Lewis | Joy in Childhood | BEATS | |||||
| Hsu, Lewis | IL Dept of Public Health (IDPH) | Medical Services for Newborns and Children with Sickling Hemoglobinopathies | |||||
| Hsu, Lewis | Medical University South Carolina (Prime sponsor: NIH) | DISPLACE | |||||
| Hsu, Lewis | Child’s Play | Virtual Reality Therapy | |||||
| John, Eunice | Children’s Hospital of Philadelphia (Prime sponsor: NIH) | Chronic Kidney Disease in Children | |||||
| Martinez, Mario | Improving Children’s Oncology Group Clinical Trials Enrollment Through a Novel Tri-institutional Program and the Effect on Racial Disparity | ||||||
| Monick, Sarah | Reducing Health Disparities among Adolescents & Young Adults (AYA) by Improving their Access to Children’s Oncology Group (COG) Clinical Trials | ||||||
| Padem, Nurcicek | Evaluation of Atopy as a Pre-Existing Risk Factor for Hypersensitivity to Asparaginase in Patients with Pediatric Acute Lymphoblastic Leukemia | ||||||
| Pillers, De-Ann | IL Dept of Public Health (IDPH) | University of Illinois Administrative Perinatal Center | |||||
| Pillers, De-Ann | Gerber Foundation | Optimizing Intravenous Protein Nutrition in Premature Infants Using Urine Metabolomics | |||||
| Pillers, De-Ann | Duke Clinical Research Institute (Prime Sponsor: NIH) | Safety of Furosemide in Premature Infants at Risk of Bronchopulmonary Dysplasia | |||||
| Schmidt, Mary | Children’s Oncology Group/Children’s Hospital of Philadelphia (Prime sponsor: NIH), St Baldrick’s Foundation, Circle of Service Foundation | Many cancer studies | |||||
| Smith, Renee | Tulane Education Fund (Admin) | Pediatric HIV/AIDS Cohort Study- Tulane | UIC is one of 14 sites across the country and Puerto Rico enrolling pregnant women who are HIV-positive in the Surveillance Monitoring for ART Toxicities study (SMARTT) study to examine the long-term safety of fetal and infant exposure to prophylactic antiretroviral (ART) chemotherapy. https://phacsstudy.org/ | ||||
| Srinivasant, Nishant | A Retrospective Analysis of Acute Kidney Injury in VLBW Infants | ||||||
| Srinivasant, Nishant | Univ of WA (Primary sponsor: NIH NINDS) | Preterm Epo Neuroprotection Trial (PENUT Trial) CCC | https://penut-trial.org/ | ||||
| PI | Funder | Title | Description |
| Abdelrahman, Badreldin | Work related stress and patient safety in UIC hospital NICU | ||
| Barnes, Michelle | Chicago (IL) City (Public Schools) | Beginnings: A University Partnership Program -Healthy Steps (PIHV-Prevention Initiative Home Visiting) | |
| Barnes, Michelle | American Academy of Pediatrics | Early Childhood Education and Medical Homes | |
| Bernstein, Karen | Does Choice of Contraceptive Method influence frequency of STI screening and rates of STI’s among Adolescents and Young adults in an Urban Academic Setting | ||
| Bernstein, Karen | Management & Training Corporation- Chicago Job Corp | Adolescent Medicine Clinical and Educational Site- Paul Simon Chicago Job Corps Center | |
| Chan, Jacqueline | Measuring the Transition Readiness of Adolescents with Type 1 Diabetes Mellitus using Transition Readiness Assessment Questionnaire (TRAQ) | ||
| Chang, Jennifer | Adherence to Long-term Follow-Up Screening Guidelines in Minority Childhood Cancer Survivors and Associated Impact on Cardiovascular Health Outcomes | ||
| Fitzgibbon, Marian | NIH | Mediterranean diet, weight loss, and cognition in obese older adults | https://projectreporter.nih.gov/project_info_description.cfm?aid=9302828&icde=38450015&ddparam=&ddvalue=&ddsub=&cr=2&csb=default&cs=ASC&pball= |
| Fitzgibbon, Marian | NIH | Cancer Education and Career Development Program | https://projectreporter.nih.gov/project_info_description.cfm?aid=9244745&icde=38450002&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC&pball= |
| Harijith, Anantha | Retrospective chart review of accidental extubation in neonates | ||
| Kenan, Kristen | UCLA | Healthy Minds, Healthy Children, Healthy Chicago (H3) | http://hss.semel.ucla.edu/portfolio/h3-tracker/ |
| Klein, Jonathan | U of MN | Healthy Youth Development Prevention Research Center – CASH: confidential Adolescent Sexual Health Services | |
| Klein, Jonathan | American Academy of Pediatrics (Merck) | AAP Contract for Adolescent Health Consortium project: Connecting Adolescents and Young Adults to Preventive Health Care Services | Funded by the Merck Foundation through a grant to the American Academy of Pediatrics, this project aims to improve the quality of adolescent and young adult preventive services and promote the inclusion of private, confidential one-on-one interactions between clinicians and youth during routine primary care encounters. The project also convenes a coalition of the American Academy of Pediatrics, American Academy of Family Physicians, American Congress of Obstetricians and Gynecologists, and the Society for Adolescent Health and Medicine to address education and implementation of research findings to improve delivery of preventive care to young people and their families. Lead research partners for the project are based at the University of Illinois at Chicago and Columbia University Mailman School of Public Health. |
| Klein, Jonathan | American Academy of Pediatrics (Prime sponser: FAMRI) | AAP Julius B. Richmond Center of Excellence | The American Academy of Pediatrics (AAP) Julius B Richmond Center is dedicated to the elimination of childrens’ exposure to tobacco and secondhand smoke by changing the clinical practice of pediatrics through the development and dissemination of practice tools; research; and improvement of community health. The Richmond Center is funded by the Flight Attendant Medical Research Institute and other public and private grants, and is based at the AAP with affiliated site and investigators at 7 academic medical centers. The Richmond Center works to create a healthy environment for children, adolescents, and families through public education and through the translation of research into practice and policy in clinical care and in communities in the US and globally. Current projects include surveys of the social climate of tobacco control, a rapid nanotechnology device for secondhand smoke measurement, a microbiome and respiratory illness project, replication of parent secondhand smoke interventions in China and Kenya, and others. Dr. Klein serves as the Scientific Director of the Center. |
| Laurent, Stacy | Rush Univ Medical Ctr (Prime sponsor: AHRQ) | Parent Training in Pediatric Primary Care: A Self Directed Tablet Based Approach | https://projectreporter.nih.gov/project_info_description.cfm?aid=9322300&icde=38450074&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC&pball= |
| Laurent, Stacy | Refusal of intramuscular vitamin K prophylaxis in newborns | ||
| Magyar, Matthew | Electronic Nicotine Delivery System Perceptions and Knowledge Among Pediatric and Internal Medicine – Pediatric Residency Trainees | ||
| Martin, Molly | NIH: NHLBI | The Asthma Action at Erie Trial | http://asthmaaction.ihrp.uic.edu/ |
| Martin, Molly | NIH: NIDCR | Coordinated Oral Health Promotion (CO-OP) Chicago | https://co-opchicago.ihrp.uic.edu/ |
| Martin, Molly | Rush Univ Medical Ctr (Prime sponsor: NIH NIDDK) | Multi-Clinic Action Trial to Control Hyperglycemia and Hypertension | https://projectreporter.nih.gov/project_info_description.cfm?aid=8630802&icde=0 |
| Martin, Molly | Rush Univ Medical Ctr (Prime sponsor: NIH) | Value and Mechanisms of Home Visitation in Obesity Interventions for Low-Income Children | https://projectreporter.nih.gov/project_info_description.cfm?aid=9415406&icde=38450162&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC&pball= |
| Minier, Mark | Circle of Service Fdn Inc | Medical Legal Partnership | |
| Morales, Erin | Pediatric Resident Assessment of Unmet Needs and Adverse Childhood Experiences | ||
| Osta, Amanda | Addressing Social Key Questions for Helping Experienced Adversity in Life to Heal: the ASK Questions for HEALTH study | ||
| Osta, Amanda | Pediatrics Milestones Assessment Collaborative | ||
| Raghavan, Aarti | Neutral Head Positioning in Preventing Intraventricular Hemorrhage | ||
| Raghavan, Aarti | Pulmonary Hypertension increases length of NICU stay, mortality and social worker use | ||
| Rao, Anita | Incidence of Necrotizing Enterocolitis in the Neonatal Intensive Care Unit | ||
| Ronayne, James | The LEAD Experience | ||
| Russo, Chloe | Developing a Tool to Evaluate Patient-Provider Communication & Patient Satisfaction in Adult Asthma Management | ||
| Saoud, Kathleen | Connecting Early Childhood Education and Medical Homes | ||
| Saulsberry, Alexandria | African American Parent Management of Children with ADHD Focus Group Study | ||
| Shah, Reshma | NIH: NIDHC | Promoting Early Child Development in Primary Care in Low Income Families | https://projectreporter.nih.gov/project_info_description.cfm?aid=9356562&icde=38451571&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC&pball= |
| Shah, Reshma | SDBP | Sit Down and Play | |
| Sierra-Fernandez, Hernan | Impact of an NICU rounding report on resident’s time utilization and workload | ||
| Smith, Sarah Boblick | Reducing Excessive Variation in Infant Sepsis Evaluations | ||
| Solomon, Marla | M&P Food Communications | Dreamfields 50 States/ 50 Plates 2013 Health Initiative Individual Award | |
| Solomon, Marla | Lilly | Diabetes Care in Schools: An Educational Program for School Nurses and Delegated Care Aids | |
| Solomon, Marla | Medtronic Inc | Diabetes Care in Schools: An Educational Program for School Nurses and Delegated Care Aids | |
| Srivastava, Pavan | Validation of a Pediatric Clinical Judgment Exercise in Assessing Entrustability of Fourth Year Medical Students in Critical Clinical Decision-Making | ||
| Tam, Michael | Opportunity Costs of Sickle Cell Disease | ||
| Van Voorhees, Benjamin | NIH | Primary Care Internet-based Depression Prevention For Adolescents (Catch-It) | |
| Van Voorhees, Benjamin | US Dept of Health & Human Services (Centers for Medicare & Medicaid Services) | University of Illinois CHECK (Coordination of Healthcare for Complex Kids) | |
| Villamizar, David Gonzalez | Defining Key Factors in Burnout and Resilience in Pediatric Residents and the Relationship to Performance |
| PI | Funder | Title | Description |
| Baynard | Lurie (Primary sponsor: NIH) | The pro-inflammatory effects of acute exercise in children with sickle cell anemia | https://projectreporter.nih.gov/project_info_description.cfm?aid=9287646&icde=38451581&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC&pball= |
| Chau, Felix | Novartis Pharmaceuticals Corp | A Randomized, Controlled Study Evaluating the Efficacy and Safety of Ranibizumab Compared with Laser Therapy for the Treatment of Infants Born Prematurely with Retinopathy of Prematurity | |
| Dudek, Steven | NIH | Cortactin in Regulation of Pulmonary Vascular Permeability | https://projectreporter.nih.gov/project_info_description.cfm?aid=9324313&icde=38451593&ddparam=&ddvalue=&ddsub=&cr=3&csb=default&cs=ASC&pball= |
| Gordeuk, Victor | Univ of Pittsburgh | A Phase IIb Randomized, Double-Blind, Placebo Controlled Multi-Center Study Assess the Safety, Tolerability and Efficacy of Riociguat in Patients with SCD (STERIO-SCD) | |
| Gordeuk, Victor | Global Blood Therapeutics | A Phase 3 Double Blind Randomized Placebo Controlled Multi Center Study of GBT440 Administered Orally to Patients with Sickle Cell Disease | |
| Gordeuk, Victor | Incyte | A Phase 1 Open-Label, Dose-Escalation Study to Evaluate Safety, Pharmacokinetic and Biological Activity of INCB059872 in Subjects with Sickle Cell Disease | |
| Gordeuk, Victor | inVentiv | A Phase 1B, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-04447943, Co-Aministered with and Wwithout Hydroxyurea | |
| Gordeuk, Victor | Global Blood Therapeutics | A Phase 2A open Label, Multiple Dose Study Evaluate the Pharmacokinetics, Safety, Tolerability and Exploratory Treatment of GBT440 in Adolescents with SCD- Part B | |
| Gordeuk, Victor | Global Blood Therapeutics | A Phase 2A Open Label, Single Dose Study to Evaluate the Pharmacokinetics, Safety, tolerability and Exploratory Treatment of GBT440 in Adolescents with SCD- Part A | |
| Gordeuk, Victor | NIH | Improving Sickle Cell Care in Adolescents and Adults in Chicago | https://projectreporter.nih.gov/project_info_description.cfm?aid=9326337&icde=38451618&ddparam=&ddvalue=&ddsub=&cr=3&csb=default&cs=ASC&pball= |
| Hynes, Denise | Chicago Community Trust | Chicago Area Patient Centered Outcomes Research Network (CAPriCORN) | www.capricorncdrn.org The Chicago Area Patient-Centered Outcomes Research Network (CAPriCORN) is an unprecedented partnership of research institutions, clinicians, patients and patient advocates. The CAPriCORN mission is to develop, test, and implement policies and programs that will improve health care quality, health outcomes, and health equity for the richly diverse populations of the metropolitan Chicago region and beyond. Within the Chicago metropolitan area, CAPriCORN seeks to address the needs of an estimated 9.5 million residents, including groups that experience significant health inequities partly due to variable access to high-quality care. One of 13 clinical data research networks (CDRNs) funded by the Patient-Centered Outcomes Research Institute (PCORI), CAPriCORN is able to contribute data and expertise to strengthen the capacity of PCORnet to engage in sustainable, population-wide, and patient-centered outcomes research. |
| Johnson, Jeremy | US Dept of Agriculture (Natl Inst of Food & Agriculture)(fmr CREES) | Rosemary as a Food Preservative: Implications for Gastrointestinal Health | |
| Machado, Roberto | NIH | Vascular- Targeted Genomic and Genetic Strategies for Acute Chest Syndrome. | https://projectreporter.nih.gov/project_info_description.cfm?aid=9523040&icde=38451643&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC&pball= |
| Mehta, Dolly | NIH | Mechanisms of endothelial regeneration and resolution of lung vascular injury | https://projectreporter.nih.gov/project_info_description.cfm?aid=9301879&icde=38451649&ddparam=&ddvalue=&ddsub=&cr=4&csb=default&cs=ASC&pball= |
| Moore, Terry | NIH | Non-Covalent Nrf2 Activators for the Treatment of Chronic Wounds | Chronic, non-healing wounds of the skin are serious medical complications that affect over 6.5 million Americans, especially older adults. These wounds include pressure sores, diabetic foot ulcers and venous ulcers. There are numerous surgical and dressing treatments for these wounds, but because there are over 70,000 lower-limb amputations each year arising from these wounds, it is clear that new treatments are needed. Strikingly, there are almost no pharmaceutical therapies to accelerate healing of chronic wounds. A major contributor to chronic wounds is a prolonged inflammatory state, and reducing inflammation may be a way to accelerate healing of chronic wounds. Unfortunately, many commonly used anti-inflammatory drugs hinder chronic wound healing; thus, new ways of reducing inflammation are needed. An essential factor in wound healing and an important regulator of inflammation is Nrf2, a transcription factor that induces many cytoprotective and antioxidant genes. As seen in other inflammatory disorders, activating Nrf2 could be a useful therapeutic strategy to treat chronic skin wounds. There are a number of covalent Nrf2 activators, but they are not selective for Nrf2, which is problematic because some of the off-target effects of these molecules are at proteins that hinder chronic wound healing. Thus, pharmacologic activation of Nrf2 with non-covalent small molecules will accelerate wound healing, which could lead to new therapeutics to treat chronic wounds. Our lab, in collaboration with Drs. DiPietro and Reddy labs at UIC, are using metabolism and pharmacokinetics studies, to develop high-affinity, metabolically stable, in vivo probes of Nrf2 activation for chronic wounds. These experiments are significant because they will develop novel in vivo probes of non-covalent Nrf2 activation, and they are innovative because they will open up new therapeutic strategies to treat chronic wounds. |
| Powell, Lisa | US Dept of Health & Human Services (CDC) | SIP 14-022 Global and Territorial Health Research Collaborating Center: Illinois PRC | |
| Raja, Sheela | Patient Perceptions about Sensitive Healthcare Questions | ||
| Royston, Thomas | NIH | Acquisition of Hyperpolarized Gas System for Lung MR Imaging | The University of Illinois at Chicago (UIC) has a large research mission focused on diagnosis and treatment of lung diseases, including lung cancer, radiation-induced lung injury, acute respiratory distress syndrome, sickle cell-linked acute chest syndrome, acute lung injury and transplant obliterative bronchiolitis. UIC also has significant expertise and facilities for developing and conducting research utilizing magnetic resonance imaging (MRI). Conventional proton (1H) MRI does not work well in the lungs due to the abundance of air. Over the past few decades hyperpolarized noble gas MRI has been shown to provide tremendous ability and insights in imaging lung disease and response to treatment. Using xenon (129Xe) gas has the added benefit that it can quantify how well gas is being exchanged in the lungs into the blood stream and tissue. We will acquire a commercial system for generation of 129Xe to catalyze the advances of our ongoing NIH-funded lung research. Additionally, this device will be a resource available not only to researchers at UIC, but also at neighboring Rush University Medical Center, Jesse Brown VA, Northwestern University, Loyola University Medical School, and University of Chicago. Existing agreements between these institutions and UIC facilitate shared usage of core instrumentation. |
| Zenk, Shannon | NIH: NCI | Environmental Attributes and Weight Control: Study of Over 1.3 Million Veterans | http://waves.uic.edu/ |