Bisheng Zhou
Assistant Professor
Department of Pharmacology & Regenerative Medicine
Contact
Building & Room:
COMRB 4113
Address:
909 S. Wolcott Ave.
Email:
Related Sites:
Selected Grants
NIH, Perivascular macrophages - a new player in regulating endothelial repair following lung vascular injury, PI
NIH, Aerocyte-mediated Alveolar Epithelial Regeneration following Lung Injury, PI
Selected Publications
- Zhou, B., Magana, L., Hong, Z., Huang, L.S., Chakraborty, S., Tsukasaki, Y., Huang, C., Wang, L., Di, A., Ganesh, B., et al. (2020). The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic-epigenetic reprogramming and resolves inflammatory injury. Nature Immunology 21, 1430-1443. 10.1038/s41590-020-0764-8.
- Zhou, B., Zeng, S., Li, N., Yu, L., Yang, G., Yang, Y., Zhang, X., Fang, M., Xia, J., and Xu, Y. (2017). Angiogenic factor with G Patch and FHA domains 1 (Aggf1) is a novel regulator of vascular injury. Arterioscler Thromb Vasc Biol 37, 675-684. 10.1161/ATVBAHA.117.308992.
- Zhou, B., Zeng, S., Li, L., Fan, Z., Tian, W., Li, M., Xu, H., Wu, X., Fang, M., and Xu, Y. (2016). Angiogenic factor with G patch and FHA domains 1 (Aggf1) regulates liver fibrosis by modulating TGF-beta signaling. Biochim Biophys Acta 1862, 1203-1213. 10.1016/j.bbadis.2016.02.002.
- Zhou, B., Si, W., Su, Z., Deng, W., Tu, X., and Wang, Q. (2013). Transcriptional activation of the Prox1 gene by HIF-1alpha and HIF-2alpha in response to hypoxia. FEBS Lett 587, 724-731. 10.1016/j.febslet.2013.01.053.
- Zhou, B., Ma, R., Si, W., Li, S., Xu, Y., Tu, X., and Wang, Q. (2013). MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth. Cancer Lett 333, 159-169. 10.1016/j.canlet.2013.01.028.
Education
PhD, Huazhong University of Science & Technology; Biochemistry & Molecular Biology (2013)
Professional Memberships
NAVBO, ATS, AHA
Research Currently in Progress
At the Zhou Laboratory, we conduct interdisciplinary research in vascular biology, immunology, and regenerative medicine, focusing on the lung vascular niche — a specialized microenvironment within the lungs comprising endothelial cells (ECs), perivascular cells, immune cells, and the extracellular matrix (ECM). Our aim is to elucidate the interplay between these cells within the lung vascular niche and their roles in lung injury, repair, and regeneration. Our long-term goal is to identify therapeutic targets and develop innovative strategies to effectively treat severe lung conditions such as Acute Respiratory Distress Syndrome (ARDS) and Idiopathic Pulmonary Fibrosis (IPF), which currently lack effective medications.