Jindpreet Kondola
Predoctoral Trainee
Department of Pharmacology & Regenerative Medicine
Advisor: Sang Ging Ong, PhD Heading link
Title: Circadian rhythm of vascular function in HFpEF
Abstract: Circadian rhythm is an important regulator of numerous physiological processes, and its disruption is associated with increased risk of cardiovascular disease. Heart failure with preserved ejection fraction (HFpEF) is associated with endothelial dysfunction, but the relationship between rhythm disturbances, endothelial dysfunction, and HFpEF remains unclear. Using a systems pharmacology approach, we recently identified and obtained preliminary results that time-dependent but not chronic daily dosing of a class of drugs prevent the development of HFpEF which is associated with an improvement in microvascular function. Here, we will study the underlying mechanisms of disrupted endothelial circadian rhythm in the context of HFpEF and how this disruption can potentially be pharmacologically targeted as a therapeutic option.