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Lab Overview Heading link

Our research focuses on the roles of connexins, or gap junction proteins, in myelinating glia of the central and peripheral nervous systems. Our work utilizes cutting edge techniques in genomics, proteomics, cell biology and electrophysiology, and is yielding exciting insights into a number of human diseases. We have ongoing research projects studying the role of connexins in X-linked Charcot-Marie- Tooth disease (an inherited disease affecting brain and peripheral nerves, Pelizaeus- Merzbacher like disease, PMLD (a devastating brain disease) and Multiple sclerosis. More detailed descriptions of our ongoing research projects are available here. Our work has been funded by grants from the National Institutes of Health, the Muscular Dystrophy Association and the National Multiple Sclerosis Society.

Publications Heading link

  • Abrams C.K., Islam M, Mahmoud R, Kwon T, Bargiello TA, Freidin MM. Functional Requirement for a Highly Conserved Charged Residue at Position 75 in the Gap Junction Protein Connexin 32. (2013) J Biol Chem 288(5):3609-19. PubMed PMID:23209285
  • Caramins M., Colebatch J.G., Bainbridge M.N., Scherer S.S., Abrams C.K., Hackett E , Freidin M.M., Jhangiani SN, Wang M, Wu Y, Muzny DM, Lindeman R, Gibbs RA. (2013) Exome sequencing identification of a Gjb1 missense mutation in x-linked Spinocerebellar ataxia (SCA-X1) Hum. Mol. Genet. 22: 4329-38. PMID: 23773993; PMCID: PMC3792691.
  • Abrams C.K., Scherer S.S., Flores-Obando R., Freidin M.M., Wong .S., Lamantea E., Farina L., Scaioli V., Pareyson D., Salsano E. A new mutation in GJC2 associated with subclinical leukodystrophy. (2014) J Neurol J Neurol. 261(10):1929-38. doi:10.1007/s00415-014-7429-1. PMID: 25059390; PMCID: PMC4301586.
  • Freidin M., Asche-Godin S., Abrams C.K.. Gene expression profiling studies in regenerating nerves in a mouse model for CMT1X: Uninjured Cx32-knockout peripheral nerves display expression profile of injured wild type nerves. (2015) Exp Neurol. Jan;263:339-49. doi: 10.1016/j.expneurol. 2014.10.014. Epub 2014 Oct 23. PubMed PMID: 25447941.
  • Olympiou M., Sargiannidou I., Markoullis K., Karaiskos C., Kagiava A., Kyriakoudi, S., Abrams C. K., Kleopa K.A. Systemic inflammation disrupts oligodendrocyte gapjunctions and induces ER stress in a model of CNS manifestations of X-linkedCharcot-Marie-Tooth disease. (2016) Acta Neuropathol Commun. 4(1):95. doi:10.1186/s40478-016-0369-5. PubMed PMID: 27585976; PubMed Central PMCID: PMC5009701.
  • Abrams, C.K.,. Mikhail Goman M. Sarah Wong S., Scherer S.S., Kleopa K.A., Peinado A., Freidin M.F. Loss of Coupling Distinguishes GJB1 Mutations Associated with CNS Manifestations of CMT1X from Those Without CNS Manifestations. (2017) Sci Rep. Jan 10;7:40166. doi:10.1038/srep40166. PubMed PMID: 28071741.
  • Abrams C.K. Diseases of connexins expressed in myelinating glia. Neurosci Lett.2017 May 23. pii: S0304-3940(17)30433-0. doi: 10.1016/j.neulet.2017.05.037. PubMed PMID: 28545922.

Current Research Heading link

Our Team Heading link

Lab Personnel

Charles Abrams

Post Doctorates

  • Dr. Alejandro Peinado PhD
  • Dr. Mona Freidin PhD

Graduate Students

  • Samantha Keil PhD Student

Undergraduate Students

  • Ria Parikh
  • Cissy Xiao


  • Gabriel Dungan
  • Anna Liu