MOLECULAR AND TRANSLATIONAL NEUROLOGY LABORATORY

Dr. Loeb is a practicing neurologist, epileptologist, and neuroscientist who currently holds the John S. Garvin Chair, Professor, and Head of the Department of Neurology and Rehabilitation.  He received his A.B. in Chemistry, M.D., and Ph.D. from the University of Chicago.  After completing a residency in Neurology at the Massachusetts General Hospital in Boston, he joined the faculty of Harvard Medical School where he also had fellowship training in epilepsy at Harvard’s Beth Israel Deaconess Hospital.

Dr. Loeb conducted postdoctoral work in the Department of Neurobiology at Harvard Medical School with Dr. Gerald Fischbach where he became interested in how understanding early neural development can teach us what goes wrong in human disease and suggest new treatments. This has led him to develop and patent a targeted drug that blocks neuregulin signaling and shows promise in degenerative disease that blocks neural inflammation, such as ALS.  He also directs a project to develop new treatments for human epilepsy through a large-scale systems biology project to link the genes, molecular and cellular signals that underlie the abnormal electrical activities that characterize this common neurological disorder.

Dr. Loeb is currently the director of the University of Illinois NeuroRepository and the Faculty Director of the Biomedical Informatics Core of the Center for Clinical and Translational Science where he explores how big data can help find ways to understand and treat human brain disorders.