The UIC cohort focused on men and women ages 18+ who had a diagnosis of one or more chronic diseases/conditions (excluding cancer). The cohort consisted largely of persons from racial/ ethnic minority groups (70% Hispanic or African-American) and were drawn from the inpatient/ outpatient population (and their families and friends) of the UIC Medical Center. This study began in July 2012 and completed the recruitment and clinical examination of 3800+ participants in June of 2015. This comprehensive clinical examination included assessment of medical history, demographic and socioeconomic factors, lifestyle factors, anthropometric and biological risk factors, biomarkers, nutritional factors, cognitive function, physical performance, and dental health. Data collected from the UI cohort will serve as a useful resource to examine the effect of numerous individual, socioeconomic, and sociocultural factors on chronic disease management and outcomes in racial/ ethnic minority groups.