MARIO SPAGGIARI, MD, FACS

ASSISTANT PROFESSOR OF SURGERY

Surgical Director of Living Donor Liver Transplant Program
ASTS Fellowship Program

General Profile

Specialty:

General Surgery / Transplant Surgery

Appointments:

Attending Surgeon at University of Illinois Hospital & Health Sciences System

Clinical Interests:

Transplantation of Liver, Kidney and Pancreas; Hcc; Cholangiocarcinoma; Colorectal Liver Metastasis

Languages Spoken:

Italian, English

Education

Medical Education:

University of Modena & Reggio Emilia, School of Medicine, Modena, Italy

Residency:

University of Modena & Reggio Emilia, Policlinico di Modena, Italy

Fellowship:

Multi-Organ Transplantation and Hepatobiliary Fellowship,Cleveland Clinic Foundation, Cleveland, OH

Second Fellowship:

Islet and Pancreas Transplantation Fellowship, University of Illinois at Chicago,Chicago, IL

Certifications:

Italian Board of Medicine and Surgery, ECFMG Certification,USMLE STEP 3

Publications, Awards, & Memberships

Society Memberships:

SITO: Italian Society of Organ Transplantation (2007)
Italian Medical and Surgical Society (Ordine dei Medici) (2007)
ESOT: European Society of Organ Transplantation (2007)
ASTS: American Society of Transplant Surgeons (2013)

Publications:

• Nazzal MD, Kawamura N, El-Gazzaz G, Spaggiari M, Abu-Elmagd K. Peritoneal decortication: an innovative technique for treatment of obstructive sclerosing encapsulating peritonitis. Am Surg. 2015 Apr;81(4):E143-5

• Quintini Cristiano; Spaggiari Mario; Hashimoto Koji; Aucejo Federico; Diago Teresa; Fujiki Masato; Winans Charles; D’Amico Giuseppe; Trenti Loris; Kelly Dympna;Eghtesad Bijan; Miller Charles. The Safety and Effectiveness of Reno-Portal By Pass in Patients with complete Portal Vein Thrombosis: Our Analysis on 10 patients. Liver Transplantation Journal.

• Guerrini GP, Gerunda GE, Montalti R, Ballarin R, Cautero N, De Ruvo N, Spaggiari M, Di Benedetto F. Results of salvage liver transplantation. Liver Int. 2014 Feb 12.

• Di Benedetto F, D’Amico G, Spaggiari M, Tirelli U, Berretta M. Onco-surgical management of colo-rectal liver metastases in older patients: a new frontier in the 3rd millennium. Anticancer Agents Med Chem. 2013 Nov;13(9):1354-63.

• Montalti R, Mimmo A, Rompianesi G, Di Gregorio C, Serra V, Cautero N, Ballarin R, Spaggiari M, Tarantino G, D’Amico G, De Santis M, De Pietri L, Troisi RI, Gerunda GE, Di Benedetto F. Absence of viable HCC in the native liver is an independent protective factor of tumor recurrence after liver transplantation. Transplantation. 2014 Jan 27;97(2):220-6.

• D’Amico G, Tarantino G, Spaggiari M, Ballarin R, Serra V, Rumpianesi G, Montalti R, De Ruvo N, Cautero N, Begliomini B, Gerunda GE, Di Benedetto F. Multiple ways to manage portal thrombosis during liver transplantation: surgical techniques and outcomes. Transplant Proc. 2013 Sep;45(7):2692-9.

• Oberholzer J, Giulianotti P, Danielson KK, Spaggiari M, Bejarano-Pineda L, Bianco F, Tzvetanov I, Ayloo S, Jeon H, Garcia-Roca R, Thielke J, Tang I, Akkina S, Becker B, Kinzer K, Patel A, Benedetti E. Minimally Invasive Robotic Kidney Transplantation for Obese Patients Previously Denied Access to Transplantation. Am J Transplant. 2013 Mar;13(3):721-8.

• Tzvetanov I, Spaggiari M, Joseph J, Jeon H, Thielke J, Oberholzer J, Benedetti E. The use of bortezomib as a rescue treatment for acute antibody-mediated rejection: report of three cases and review of literature. Transplant Proc. 2012 Dec;44(10):2971-5.

• Tzvetanov I, Spaggiari M, Oberholzer J, Setty S, Stephenson A, Thielke J, West-Thielke P, Jeon H, Danielson KK, Kaplan B, Benedetti E. Cell population in spleens during antibody-mediated rejection: pathologic and clinical findings. Transplantation 2012 Aug 15;94(3):255-62.

• Tzvetanov I, Spaggiari M, Jeon H, Roca RG, Bhati C, Oberholzer J, Benedetti E.&The role of splenectomy in the setting of refractory humoral rejection after kidney transplantation. Transplant Proc. 2012 Jun;44(5):1254-8.

• Tzvetanov I, Spaggiari M, Jeon H, Garcia-Roca R, Osipova M, Jose O, Enrico B. Renal artery aneurysm in robotic donor nephrectomy: a case report.Exp Clin Transplant.2012 Jun;10(3):293-5.

• Di Benedetto F, Ballarin R, Spaggiari M, Pecchi A, Gerunda GE. Role of intraoperative ultrasonography for pancreatic schwannoma. J Surg Oncol. 2012 Jan 3.

• Ghafari J, Tzvetanov I, Spaggiari M, Jeon H, Oberholzer J, Benedetti E. The effect of small bowel living donation on donor lipid profile. Transpl Int. 2012 Jan;25(1):e19-20.

• Giulianotti PC, Tzvetanov I, Jeon H, Bianco F, Spaggiari M, Oberholzer J, Benedetti E. Robot-assisted right lobe donor hepatectomy. Transpl Int. 2012 Jan;25(1):e5-9.

• Tzvetanov I, Spaggiari M, Jeon H, Bhati C, Hassan S, Joseph J, Heinrich L, Thielke J,Setty S, Oberholzer J, Benedetti E. Rescue splenectomy in a case of humoral rejection in ABO incompatible simultaneous liver kidney transplantation. Transplantation. 2012
Jan 27;93(2):e1-2.

• Di Benedetto F, Berretta M, D’Amico G, Montalti R, De Ruvo N, Cautero N, Guerrini GP, Ballarin R, Spaggiari M, Tarantino G, Di Sandro S, Pecchi A, Luppi G, Gerunda GE. Liver resection for colorectal metastases in older adults: a paired matched analysis. J Am Geriatr Soc. 2011 Dec;59(12):2282-90.

• Ballarin R, Spaggiari M, Cautero N, De Ruvo N, Montalti R, Longo C, Pecchi A, Giacobazzi P, De Marco G, D’Amico G, Gerunda GE, Di Benedetto F. Pancreatic metastases from renal cell carcinoma: The state of the art. World J Gastroenterol. 2011 Nov 21;17(43):4747-56.

• Ballarin R, Montalti R, Spaggiari M, Cautero N, De Ruvo N, Guerrini GP, Rompianesi G, Longo C, Gerunda GE, Di Benedetto F. Liver transplantation in older adults: our point of view. J Am Geriatr Soc. 2011Jul;59(7):1359-61.

• Di Benedetto F, Tarantino G, De Ruvo N, Cautero N, Montalti R, Guerrini GP, Ballarin R, Spaggiari M, Smerieri N, Serra V, Rompianesi G, D’Amico G, Mimmo A, Iemmolo RM Codeluppi M, Cocchi S, Guaraldi G, Gerunda GE. University of Modena Experience in HIV-Positive Patients Undergoing Liver Transplantation. Transplant Proc. 2011 May;43(4):1114-8.

• Di Benedetto F, D’Amico G, De Ruvo N, Cocchi S, Montalti R, Cautero N, Guerrini GP,Ballarin R, Spaggiari M, Tarantino G, Baisi B, Cappelli G, Gerunda GE. Combined liver-kidney transplantation in patients infected with human immunodeficiency virus. Transpl Infect Dis. 2011 Mar 17.

• Ballarin R, Cucchetti A, Spaggiari M, Montalti R, Di Benedetto F, Nadalin S, Troisi RI,Valmasoni M, Longo C, De Ruvo N, Cautero N, Cillo U, Pinna AD, Burra P, GerundaGE. Long-Term Follow-Up and Outcome of Liver Transplantation From Anti- Hepatitis C Virus-Positive Donors: A European Multicentric Case-Control Study.Transplantation. 2011 Jun 15;91(11):1265-1272.

• Spaggiari M, Di Benedetto F, Ballarin R, Cautero N, De Ruvo N, Montalti R, Guerrini G, Gerunda GE. Primary squamous cell carcinoma of the liver associated with Caroli’s disease: case report and review of the literature. Onkologie 2011;34(4):193-5.

• Ballarin R, Spaggiari M, Di Benedetto F, Montalti R, De Ruvo N, Cautero N, Losi L,Bagni A, D’Errico A, Gerunda GE, Gerunda GE. No age limit for liver transplant donors. J Am Geriatr Soc. 2010 Sep;58(9):1816-8.

• Cautero N, Di Benedetto F, De Ruvo N, Montalti R, Guerrini GP, Ballarin R, Spaggiari M, Smerieri N, De Blasiis MG, Rompianesi G, Iemmolo RM, Marino M, Bertolotti M,Zivieri S, Gerunda GE. Novel genetic mutation in apolipoprotein E2 homozygosis and
its implication in organ donation: a case report.!Transplant Proc. 2010 May;42(4):1349-51.

• Di Benedetto F, Mimmo A, D’Amico G, De Ruvo N, Cautero N, Montalti R, Guerrini GP, Ballarin R, Spaggiari M, Tarantino G, Serra V, Pecchi A, De Santis M, Gerunda GE. Liver transplantation due to iatrogenic injuries: two case reports. Transplant Proc. 2010 May;42(4):1375-7.

• Spaggiari M, Ballarin R, di Benedetto F, Montalti R, de Ruvo N, Cautero N, Guerrini G,Gerunda GE. Does HIV-related cholangiopathy exist in the setting of liver transplantation? AIDS. Apr 24;24(7):1072-5.

• Ballarin R, Spaggiari M, Di Benedetto F, De Ruvo N, Cautero N, Montalti R, Guerrini GP, Longo C, Mimmo A, D’Amico G, Gerunda GE. Is there an age limit for radical surgery in case of tumors infiltrating the duodenum? Minerva Chir. 2010 Feb;65(1):1-9.

• Di Benedetto F, Di Sandro S, De Ruvo N, Montalti R, Ballarin R, Guerrini GP,Spaggiari M, Guaraldi G, Gerunda G. First report on a series of HIV patients
undergoing rapamycin monotherapy after liver transplantation. Transplantation. 2010 Mar 27;89(6):733-8.

• Di Benedetto F, Ballarin R, De Ruvo N, Berretta M, Spaggiari M, Montalti R, Guerrini GP, Gerunda GE. Pancreatic resections for malignancy in patients aged 70 and older. J
Am Geriatr Soc. 2009 Jul;57(7):1323-4.

• Di Benedetto F, Di Sandro S, De Ruvo N, Montalti R, Guerrini GP, Ballarin R, Spaggiari M, Mimmo A, D’Amico G, Cautero N, Iemmolo RM, Gerunda GE. Immunosuppressive switch to sirolimus in renal dysfunction after liver transplantation.Transplant Proc. 2009 May;41(4):1297-9.

• Spaggiari M, Di Benedetto F, Masetti M, Ballarin R, Romano A, Pietrangelo A,Gerunda GE. The impact of inherited thrombophilia on liver transplantation.Transplantation. 2009 Apr 15;87(7):1103-4.

• Ballarin R, Di Benedetto F, De Ruvo N, Masetti M, Montalti R, Spaggiari M, Longo C,Gerunda GE. Thrombosis of developmental venous anomalies of the brain after livertransplantation. Transplantation. 2009 Feb 27;87(4):615-6.

• Ballarin R, Masetti M, Losi L, Di Benedetto F, Di Sandro S, De Ruvo N, Montalti R,Romano A, Guerrini GP, De Blasiis MG, Spaggiari M, Gerunda GE. Cystic pancreatic neuroendocrine neoplasms with uncertain malignant potential: report of two cases.Surg Today. 2009;39(2):162-7.

• Di Benedetto F, Di Sandro S, De Ruvo N, Spaggiari M, Montalti R, Ballarin R, Cappelli G, Gerunda GE. Sirolimus Monotherapy Effectiveness in Liver Transplant Recipients With Renal Dysfunction Owing to Calcineurin Inhibitors. J Clin Gastroenterol.2008 Dec 3.

• Ballarin R, Spaggiari M, Di Benedetto F, Montalti R, Masetti M, De Ruvo N, Romano A, Guerrini GP, De Blasiis MG, Gerunda GE. Do not Deny Pancreatic Resection to Elderly Patients. J Gastrointest Surg. 2008 Sep 11.

• Ballarin R, Di Benedetto F, Masetti M, Spaggiari M, De Ruvo N, Montalti R, Romano A, Cocchi S, Guaraldi G, Gerunda GE. Combined liver-kidney transplantation in an HIV-HCV- coinfected patient with haemophilia. AIDS. 2008 Oct 1;22(15):2047-2049.

• Di Benedetto F, Di Sandro S, De Ruvo N, Berretta M, Montalti R, Guerrini GP, Ballarin R, De Blasiis MG, Spaggiari M, Smerieri N, Iemmolo RM, Guaraldi G, Gerunda GE. Human immunodeficiency virus and liver transplantation: our point of view. Transplant Proc. 2008 Jul-Aug;40(6):1965-71.

• Masetti M, Rompianesi G, Montalti R, Romano A, Spaggiari M, Ballarin R, Guerrini GP, Gerunda GE. Effects of everolimus monotherapy on hematological parameters and iron homeostasis in de novo liver transplant recipients: preliminary results. Transplant Proc. 2008 Jul-Aug;(6):1947-9.

• Arzu GD, De Ruvo N, Montalti R, Masetti M, Begliomini B, Di Benedetto F,
Rompianesi G, Di Sandro S, Smerieri N, D’Amico G, Vezzelli E, Iemmolo RM, Romano
A, Ballarin R, Guerrini GP, De Blasiis MG, Spaggiari M, Gerunda GE. Temporary
porto-caval shunt utility during orthotopic liver transplantation. Transplant Proc. 2008 Jul-Aug;40(6):1937-40.

• Ravaioli M, Masetti M, Dazzi A, Romano A, Spaggiari M, Grazi GL, Ercolani G, Cescon M, Di Gioia P, De Ruvo N, Montalti R, Ballarin R, Di Benedetto F, Ridolfi L, Alvaro N, Ramacciato G, Morelli C, Gerunda E, Pinna AD. Model for End-Stage Liver
Disease (MELD) System to Allocate and to Share Livers: Experience of Two Italian
Centers. Transplant Proc. 2008 Jul-Aug;40(6):1814-5.

• Romano A, Spaggiari M, Masetti M, Sassatelli R, Di Benedetto F, De Ruvo N, Montalti R, Guerrini GP, Ballarin R, De Blasiis MG, Gerunda GE. A new endoscopic treatment for pancreatic fistula after distal pancreatectomy: case report and review of the literature Gastrointest Endosc. 2008 May 30.

• Pinna AD, Spaggiari M, Lauro A. Is there a role for “acute”” or “pre-emptive””intestinal transplantation?. Curr Opin Organ Transpl 2007 June; 12(3):261-264.

• Di Benedetto F, Spaggiari M, De Ruvo N, Masetti M, Montalti R, Quntini C, Ballarin R, Di Sandro S, Costantini M, Gerunda GE. Pancreatic schwannoma of the body involving the splenic vein: case report and review of the literature Eur J Surg Oncol. 2007 Sep;33(7):926-8. Epub 2006 Oct 16.

• Di Benedetto F, De Ruvo N, Masetti M, Cautero N, Lauro A, Montalti R, Quintini C, Di Francesco F, Romano A, Guerrini G, Ballarin R, Molteni G, Spaggiari M, Di Sandro S, Gerunda GE. Hepatic hilum management in 250 liver-multivisceral procurements. Transplant Proc. 2006 May;38(4):1068.

Book Chapters:

• Robotic Renal Surgery: Benign and Malignant Surgery for the Kidneys and Ureters edited by Ronney Abaza, MD, FACS (Springer). Chapter 4: Robotic Donor Nephrectomy: Hand-Assisted Technique Ivo G. Tzvetanov,Mario Spaggiari, Jose Oberholzer, Enrico Benedetti.