Irina Buhimschi

Irina Buhimschi, MD

Professor of Obstetrics & Gynecology,
Research Division
Director, Perinatal Research Laboratory

Academic Office:
Phone: (312)996-7006

Medical School

Residency

Carol Davila University of Medicine and Pharmacy
Bucharest Romania
University of Maryland

Biography

Dr. Irina Buhimschi is the Director of the Center for Perinatal Research in the Research Institute at Nationwide Children’s Hospital and Professor of Pediatrics and Obstetrics/Gynecology at The Ohio State University in Columbus Ohio, where she holds the John E. Fisher Endowed Chair in Perinatal and Neonatal Research.

Dr. Irina Buhimschi received her M.D. degree from the Carol Davila University of Medicine and Pharmacy in Bucharest, Romania. She then completed her postgraduate and postdoctoral training at The University of Texas Medical Branch in Galveston, Texas and University of Maryland School of Medicine in Baltimore, Maryland.

Dr. Buhimschi’s research spans the broad area of molecular and pathophysiologic mechanisms for preterm labor and preeclampsia that together account for the large majority of preterm births, stillbirths and neonatal deaths. A central focus of investigation is in applying innovative technology platforms such as proteomics, genomics and metabolomics to understand and distinguish among the different causes of preterm birth with special emphasis in identifying the mechanisms accounting for racial disparities in preterm birth.

Dr. Irina Buhimschi was recruited by the Research Institute at Nationwide Children’s Hospital in 2013 from Yale University to serve as Director of the Center for Perinatal Research. During her tenure, she oversaw the academic productivity of 20 Principal Investigators conducting basic, translational, and clinical research focused on prevention of preterm birth and improvement of perinatal outcomes. As a mentor to Maternal Fetal Medicine and Neonatology fellows and faculty, Dr. Irina Buhimschi played a critical role in bridging the scholarly activity of The Ohio State University Division of Maternal Fetal Medicine and the Nationwide Children’s Hospital Department of Pediatrics. Currently, the Center for Perinatal Research is at its peak academic and scholarly productivity.

Dr. Irina Buhimschi is known for her proteomics studies that led to a new understanding of several pregnancy complications, including inflammation-induced preterm birth, preeclampsia, and preterm premature rupture of membranes. Her laboratory was the first to identify protein misfolding and proteostasis derangements similar to Alzheimer’s disease in preeclampsia. The practical application of this research has led to the Congo Red Dot test, a device that measures urine congophilia and is under development for improved detection of preeclampsia in the United States and worldwide. Because of its potential to decrease maternal and neonatal mortality, the Congo Red Test received the Patents for Humanity Award from the United States Patent and Trademark Office (USPTO), an award reserved for game-changing technology that meets global humanitarian challenges.

Dr. Buhimschi has mentored numerous medical and graduate students, clinical fellows, and young faculty. She has published more than 180 peer-reviewed publications and is the inventor on 12 patents. Her work has received numerous awards of excellence at national and international meetings. Dr. Irina Buhimschi’s research has been funded by the National Institutes of Health (NIH), March of Dimes and Bill and Melinda Gates Foundation among others. Currently, she is Principal Investigator on an NIH RO1 grant and a Saving Lives at Birth (SL@B) Transition-to-Scale grant from the United States Agency for International Development (USAID) to implement the Congo Red Dot test in low-resource settings across the world. Dr. Irina Buhimschi served as Program Director for Central Ohio and Project Leader for Theme 5, which investigated the mechanism that race, immigrant status, and level of acculturation impact pregnancy outcome. Through investigation of genetic and microbiome signatures in unique populations, the project interrogates gene-environment interactions affecting gestational length. She has served on numerous grant review committees and expert panels for the NIH, March of Dimes, and other private foundations. She is also an Associate and Section Editor for Pediatric Research and a member of editorial boards for several subspecialty journals. Aside from her own research, she is passionate about motivating and inspiring the next-generation of students to pursue STEM careers. While at Nationwide Children’s Hospital, Dr. Irina Buhimschi spearheaded the Futures Matter Program, an 8-week summer research experience funded by the Eunice Kennedy Shiver National Institute of Child and Human Development (NICHD) aimed at introducing talented students from local high schools to principles of transdisciplinary research.

Recent Publications

Li J, Wang X, Ackerman WE 4TH, Batty AJ, Kirk SG, White WM, Wang X, Anastasakis D, Samavati L, Buhimschi I, Nelin LD, Liu Y. Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis. International Journal of Molecular Science 2018;19:12.

Stetson BT, Buhimschi CS, Kellert BA, Hay K, Buhimschi IA, Maitre NL. Comparison of Cerebral Palsy Severity Between 2 Eras of Antenatal Magnesium Use. JAMA Pediatrics 2018.

Nayeri UA, Buhimschi CS, Zhao G, Buhimschi IA, Bhandari V. Components of the antepartum, intrapartum, and postpartum exposome impact on distinct short-term adverse neonatal outcomes of premature infants: A prospective cohort study. PLoS One 2018;13(12).

Allen TK, Nazzal MN, Feng L, Buhimschi IA, Murtha AP. Progestins Inhibit Tumor Necrosis Factor α-Induced Matrix Metalloproteinase 9 Activity via the Glucocorticoid Receptor in Primary Amnion Epithelial Cells. Reproductive Science 2018.

Rood KM, Buhimschi CS, Zhao G, Oliver EA, Summerfield T, Bahtiyar MO, Buhimschi IA. Tenascin-x in Amniotic Fluid and Reproductive Tissues of Pregnancies Complicated by Infection and Preterm Prelabor Rupture of Membranes. Biology of Reproduction 2018.

Motawea HKB, Chotani MA, Ali M, Ackerman W, Zhao G, Ahmed AAE, Buhimschi CS, Buhimschi IA. Human Placenta Expresses α2-Adrenergic Receptors and May Be Implicated in Pathogenesis of Preeclampsia and Fetal Growth Restriction. American Journal of Pathology 2018.

Kouza M, Banerji A, Kolinski A, Buhimschi I, Kloczkowski A. Role of Resultant Dipole Moment in Mechanical Dissociation of Biological Complexes. Molecules 2018:23(8)

Ali M, Rogers LK, Heyob KM, Buhimschi CS, Buhimschi IA. Changes in Vasodilator-Stimulated Phosphoprotein Phosphorylation, Profilin-1, and Cofilin-1 in Accreta and Protection by DHA. Reproductive Sciences 2018.

Rood KM, Buhimschi IA, Jurcisek JA, Summerfield TL, Zhao G, Ackerman WE, Wang W, Rumpf RW, Thung SF, Bakaletz LO, Buhimschi CS. Skin Microbiota in Obese Women at Risk for Surgical Site Infection After Cesarean Delivery. Scientific Reports 2018;8(1):8756.

Kouza M, Co NT, Li MS, Kmiecik S, Kolinski A, Kloczkowski A, Buhimschi IA. Kinetics and mechanical stability of the fibril state control fibril formation time of polypeptide chains: A computational study. Journal of Chemical Physics 2018;148(21):215106.

For a list of Dr. Buhimschi’s publications, please click the following link: