Frank González, MD, FACOG
Associate Professor of Obstetrics & Gynecology, Division of Reproductive Endocrinology & Infertility Director, Laboratory for Reproductive Endocrine and Inflammation Research
Phone: (312) 355-2634
Fax: (312) 355-3161
Phone: (312) 355-0458
Fax: (312) 996-4238
University of Rochester
Case Western Reserve University
Dr. Frank González provides comprehensive care to couples with infertility and manages hormonal imbalances that affect menstrual function. He is a nationally recognized expert on Polycystic Ovary Syndrome (PCOS), the most common hormonal imbalance in premenopausal women. Dr. González is a formally trained physician-scientist and his lab is an integral part of his translational research program. His research is funded by the National Institutes of Health and is focused on studying the effects of nutrient-induced inflammation in the development of ovarian dysfunction, insulin resistance, β-cell dysfunction and atherogenesis in PCOS.
Dr. González completed his undergraduate studies at Harvard University in Cambridge, MA. He received his medical degree from Temple University School of Medicine in Philadelphia, PA, and completed a residency in Obstetrics & Gynecology at the Rochester General Hospital, University of Rochester School of Medicine & Dentistry in Rochester, NY. Dr. González subsequently completed a fellowship in Reproductive Endocrinology & Infertility at University Hospitals of Cleveland, Case Western Reserve University School of Medicine in Cleveland, OH.
Dr. González is board certified in Obstetrics & Gynecology as well as the subspecialty of Reproductive Endocrinology & Infertility. He is active in the American Society for Reproductive Medicine, the Androgen Excess and PCOS Society and the Endocrine Society. Dr. González is bilingual and is fluent in Spanish.
Our lab focuses on nutrient-induced inflammation in the development of key endocrine and metabolic abnormalities present in Polycystic Ovary Syndrome (PCOS); namely, ovarian dysfunction, insulin resistance, β-cell dysfunction and atherogenesis. We evaluate the mechanisms through which dietary components serve as proinflammatory triggers, and hormones serve as leukocyte sensitizers culminating in up-regulation of ovarian androgen steroidogenic and proatherothrombotic pathways, down-regulation of the insulin signaling pathway and β-cell damage in PCOS. We are currently studying the ability of nonsteroidal anti-inflammatory therapy to reduce hyperandrogenism and induce ovulation in PCOS.
Our approach involves translational studies that combine clinical research protocols for human subject interventions in a clinical research center setting with basic research techniques that evaluate inflammation at the molecular level in a laboratory setting. The overall aim is to provide clinical relevance to basic laboratory findings that bring innovation from the bench to the bedside.
Human subjects are grouped for comparison after selection by endocrine, metabolic or body composition features to control for confounders. Tissue obtained from human subjects is evaluated using a cadre of basic laboratory assays including RT-PCR, Western blotting, electrophoretic mobility shift assays, chemiluminescence, cell culture and ELISA.
Dr. González serves as the Principal Investigator of this novel research focus that has been established and perpetuated with the use of both NIH and institutional funding. Dr. González spearheads the focus by combining his clinical expertise in the care of women with PCOS, and his knowledge of clinical study design, endocrine and metabolic dynamic testing, and human subject recruitment with his formal training to oversee a basic research laboratory and troubleshoot basic research techniques.
We have a variety of collaborative investigators available in the UIC research community encompassing the fields of endocrinology and metabolism, surgery, and kinesiology and nutrition. These collaborators provide added capability with their own expertise in clinical and basic research techniques including the use of the euglycemic-hyperinsulinemic clamp (Dr. Haus), techniques to assess skeletal muscle insulin signaling (Drs. Baynard and Haus) and bariatric surgery to normalize metabolism (Dr. Elli).
Findings stemming from our lab are presented regularly at national and international scientific meetings, and have established a well-recognized brand among investigators in the field of androgen excess. Dr. González has furthered the brand by chairing national postgraduate courses that educate piers by translating research findings from our laboratory into clinical management.
Keywords Describing Research Interests:
Polycystic Ovary Syndrome, oxidative stress, inflammation, cytokines, insulin resistance, hyperglycemia, abdominal adiposity