Costa Symposium
18th Annual Robert H. Costa Memorial Lecture Heading link
"Modulation of mTOR to treat MAFLD/MASH — a circuitous story" by Dr. Zoltan Arany, MD (University of Pennsylvania, Perelman School of Medicine)
About the Symposium Heading link
The Department of Biochemistry and Molecular Genetics began the annual Robert H. Costa Memorial Lecture to honor the esteemed Dr. Costa (1957-2006) who passed away after a heroic battle with cancer. The first Robert H. Costa Memorial Lecture was given by Dr. James Darnell, Jr., Rockefeller University, who Rob joined in 1985 as a postdoctoral fellow. Rob made many important contributions to the field of cancer biology and was a leading authority in molecular analysis of liver cell proliferation. We welcome you in joining us in honoring his achievements.
Past Speakers for Costa Memorial Lecture Series Heading link
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Past Speakers
Date Title Speaker 3/19/2024 Liver fibrosis in MASH and the role of LARP6 David Brenner, MD / President and CEO at Sanford Burnham Prebys 12/7/2022 Bioengineering and Stem Cell Approaches to Improve Pulmonary Vasculature in Perinatal Lung Diseases. Vladimir V. Kalinichenko, MD/PhD / Cincinnati Children’s Hospital Medical Center 11/10/2021 Uncovering Regulatory Mechanisms That Help Determine the NF-kB-dependent Inflammatory Gene Expression Program. Sankar Ghosh, PhD / Silverstein and Hutt Family Professor and Chairman, Department of Microbiology & Immunology, Columbia University, New York, NY 10/28/2020 Metabolic phenotypes and cancer progression in humans. Ralph J. DeBerardinis, MD/PhD / Joel B. Steinberg, M.D. Chair in Pediatrics, Sowell Family Scholar in Medical Research, Chief- Division of Pediatric Genetics and Metabolism, Professor, Children’s Medical Center Research Institute (CRI), UT Southwestern Medical Center 12/4/2019 Nrf2 activation promotes lung cancer metastasis by inhibiting the Fbxo22-dependent degradation of Bach1. Michele Pagano, MD / Investigator, Howard Hughes Medical Institute, Chair, Dept. of Biochemistry & Molecular Pharmacology, New York University School of Medicine 6/13/2018 Pancreatic Cancer Biology and Medicine. David Tuveson, PhD / Roy J. Zuckerberg Professor of Cancer Research, Cold Spring Harbor Laboratory 5/18/2017 New insights into the pathogenesis of NASH and its progression to liver cancer. Michael Karin, PhD / Distinguished Professor of Pharmacology, Ben and Wanda Hildyard Chair for Mitochondrial and Metabolic Diseases, Department of Pharmacology, University of California, San Diego 9/21/2016 Epigenetics: One Genome, Multiple Phenotypes. Danny Reinberg, PhD / Howard Hughes Medical Institute, Terry and Mel Karmazin Professor of Biochemistry and Molecular Pharmacology, NYU Langone School of Medicine 4/9/2015 Hypoxia, Metabolism, and Tumor Progression M. Celeste Simon, PhD / Scientific Director and Investigator, Abramson Family Cancer Research Institute, Professor, Cell and Developmental Biology, University of Pennsylvania School of Medicine 9/9/2014 Mechanisms of Interferon Signaling. Leonidas C. Platanias, MD/PhD / Lurie Professor of Oncology, Professor of Medicine, Feinberg School of Medicine, Northwestern University 10/30/2013 Links from Fibrosis to Hepatocellular Carcinoma. Scott Friedman, MD / Director,Division of Liver Diseases, Dean for Therapeutic Discovery, Professor of Pharmacology and Systems Biology, Icahn School of Medicine at Mount Sinai 10/24/2012 Sexual Dimorphism of Liver Cancer – It All Depends on FoxA. Klaus H. Kaestner, PhD / Thomas and Evelyn Suor Butterworth Professor in Genetics, Dept. of Genetics, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine 5/18/2011 Global profiling reveals gain-of-function for p53 in liver regeneration. Michelle C. Barton, PhD / Dept. of Biochemistry & Molecular Biology, Co-Director, Center for Stem Cell and Developmental Biology, UT MD Anderson Cancer Center 4/21/2010 Pluripotent Stem Cells in the Study of Liver Development and Disease. Stephen Duncan, PhD / Director, MCW Program in Regenerative Medicine and Stem Cell Biology, Medical College of Wisconsin 4/29/2009 Mechanistic Discovery in Murine Cancer Models: From Basic Discovery to Clinical Translation. Terry Van Dyke, PhD / Director, Mouse Cancer Genetics Program, National Cancer Institute at Frederick 3/26/2008 Epigenetic Control by a Pioneer Transcription Factor, FoxA. Kenneth S. Zaret, PhD / Joseph Leidy Professor, Dept. of Cell and Developmental Biology, University of Pennsylvania 3/23/2007 Transcription Factors Are Involved in Cancer: Will Anti-Cancer Agents Follow? James Darnell, Jr., MD / Viston Astor Professor & Head, Laboratory of Molecular Cell Biology, Rockefeller University -
Robert H. Costa Memorial Symposium Program (Friday, March 23, 2007)
Robert H. Costa Memorial Symposium
Friday, March 23, 2007Session Chair: Dr. Pradip Raychaudhuri9:00–9:15 a.m.Welcoming remarks and introduction to first speaker.
Pradip Raychaudhuri PhD, Professor, Biochemistry & MolecularGenetics, University of Illinois at Chicago9:15-9:45 a.m.Jeff Whitsett, M.D., Professor, University of Cincinnati and Director of Division of Neonatology and Pulmonary Biology, Children’s Hospital Medical Center, Cincinnati.
“Transcriptional Control of Perinatal Lung Maturation: Roles of Foxa1 and Foxa2”9:55-10:25 a.m.Gretchen Darlington, PhD, Professor, Huffington Center on Aging, Baylor College of Medicine.
“Altered bile acid synthesis and xenobiotic metabolism in long lived mice”Session Chair: Dr. Angela Tyner10:50-11:20 a.m.Janardan Reddy, M.D., Magerstadt Professor and Chair, Pathology Northwestern Feinberg School of Medicine, University
“Coactivators in Hepatic responses”11:30-12:00 p.m.Stephen Duncan, D.Phil, Professor, Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin.
“The contribution of GATA factors to embryonic development of the liver and heart”Session Chair: Dr. Jack Kaplan1:30-1:40 p.m.Introduction to First Annual Robert H. Costa Memorial Lecture
Jack H. Kaplan PhD, FRS, Benjamin Goldberg Professor & Head,Biochemistry & Molecular Genetics, University of Illinois at
Chicago1:40-2:40 p.m.FIRST ANNUAL ROBERT H. COSTA LECTUREJames Darnell, Jr. M.D, Viston Astor Professor & Head, Laboratory of Molecular Cell Biology, Rockefeller University.
“Transcription Factors Are Involved in Cancer: Will Anti-Cancer Agents Follow?”2:50-3:20 p.m.Joseph Locker, M.D., PhD, Professor, Department of Pathology, Yeshiva University, Albert Einstein College of Medicine.
“A liver transcription factor in unfamiliar territory”
Session Chair:Dr. Lester Lau3:40-4:10 p.m.Brett Spear, PhD, Professor, Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky.
“Afr1: Identification and role in postnatal AFP and H19 repression in the mouse liver”4:20-4:50 p.m.Vladimir Kalinichenko, M.D., PhD, Assistant Professor, Department of Medicine, University of Chicago.
“Forkhead Box f1 Transcription Factor in Lung Development”5:00 p.m.Closing remarks