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The top ten DEGs for each neurogenic cell type among YA samples. b, The top ten DARs in gene promoters of each neurogenic cell type among YA samples. Labelled genes correspond to the overlapping promoters. Top DEGs and DARs were selected on the basis of their per cent difference in expression of all significant (q  0.3. Enriched pathways were selected on the basis of FDR < 0.05 and for nuclear gene functions for NSCs and neuroblasts. Pathways enriched in immature neurons were selected on the basis of FDR  2. d, Motif enrichment statistics of increased open chromatin in NSCs and immature neurons. DARs were based on adjusted P < 0.05. Enriched motifs were selected on the basis of FDR  1. e, Heatmap dot plot of cell-specific regulons in neurogenic cells in YA samples. The top ten most cell-specific regulons for each cell type were included if the gene-based area under the curve (AUC) change was significant (Benjamini-Hochberg (BH)-corrected, Mann–Whitney U-test, two-sided, FDR < 0.05).

Lazarov Lab Publication in Nature

Dr. Orly Lazarov and colleagues recently had their work “Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease” published in Nature. This work has also been recognized on UIC Today.

Graduate Student Award: Sarah Scheinman

Sarah Scheinman is this year’s winner of the Dr. Harry Monsen and Mildred R. Monsen Annual Award for Excellence. This is awarded annually to a graduate student who has distinguished himself or herself…

Faculty Awards: Chris Peters and Leon Tai, PhDs

Two awards recognizing outstanding faculty in the Department have been awarded from the College of Medicine. The Anatomy & Cell Biology Rising Star award recognizes Dr Chris Peters and the Anatomy and Cell…