Clinical and Academic Interests

• Metabolic and tissue functional MRI
• Molecular Imaging
• CEST (Chemical Saturation Exchange Transfer) MRI
• MR Spectroscopy
• Imaging Biomarkers
• Technical Development

• Haris M, Singh A, Cai K, Kogan F, McGarvey J, DeBrosse C, Zsido GA, Walter RT Witschey WRT, Koomalsingh K, Pilla JJ, Chirinos JA, Ferrari VA, Gorman JH, Hariharan H, Robert Gorman RC, Reddy R. A Novel Technique for In Vivo Mapping of Myocardial Creatine Kinase Metabolism. Nature Medicine. Nature Medicine (2014) doi:10.1038/nm.3436
• Cai K, Haris M, Singh A, Kogan F, Greenberg JH, Hariharan H, Detre JA, Reddy R. Magnetic Resonance Imaging of Glutamate. Nature Medicine. 2012; 18(2):302-6.
• Kogan F, Haris M, Singh A, Cai K, Debrosse C, Nanga RP, Hariharan H, Reddy R. Method for high-resolution imaging of creatine in vivo using chemical exchange saturation transfer. Magn Reson Med. 2014;71(1):164-72.
• Cai K, Singh A, Roalf DR, Nanga RP, Haris M,Hariharan H, Gur R, Reddy R. Mapping glutamate in subcortical brain structures using high-resolution GluCEST MRI. NMR Biomed. 2013; 26(10):1278-84.
• Haris M, Singh A, Cai K, Nath K, Crescenzi R, Kogan F, Hariharan H, Reddy R. MICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer’s disease. J Neurosci Methods. 2013; 212(1):87-93.
• Singh A, Cai K, Haris M, Hariharan H, Reddy R. On B(1) inhomogeneity correction of in vivo human brain glutamate chemical exchange saturation transfer contrast at 7T. Magn Reson Med. 2013 69(3):818-24.
• Xu HN, Kadlececk S, Pullinger B, Profka H, Cai K, Hariharan H, Rizi R, Li LZ. In vivo metabolic evaluation of breast tumor mouse xenografts for predicting aggressiveness using the hyperpolarized (13)C-NMR technique. Adv Exp Med Biol. 2013; 789:237-42.
• Cai K, Xu H, Singh A, Haris M, Reddy R, Li L. Characterizing Prostate Tumor Mouse Xenografts with CEST & MT MRI and Redox Scanning. Adv Exp Med Biol. 2013; 765:39-45.
• Cai K, Haris M, Singh A, Li L, Reddy R. Blood Oxygen Level Dependent Magnetization Transfer (BOLDMT) Effect. Adv Exp Med Biol. 2013; 765:31-7.
• Paudyal R, Poptani H, Cai K, Zhou R, Glickson JD. Impact of transvascular and cellular-interstitial water exchange on dynamic contrast-enhanced magnetic resonance imaging estimates of blood to tissue transfer constant and blood plasma volume. J Magn Reson Imaging. 2013;37(2):435-44.
• Cai K, Nanga RP, Lamprou L, Schinstine C, Elliott M, Hariharan H, Reddy R, Epperson CN. The Impact of Gabapentin Administration on Brain GABA and Glutamate Concentrations: A 7T (1)H-MRS Study. Neuropsychopharmacology. 2012; 37(13):2764-71.
• Kogan F, Singh A, Cai K, Haris M, Hariharan H, Reddy R. Investigation of chemical exchange at intermediate exchange rates using a combination of chemical exchange saturation transfer (CEST) and spin-locking methods (CESTrho). Magn Reson Med. 2012; 68(1):107-19.
• Haris M, Nanga RP, Singh A, Cai K, Kogan F, Hariharan H, Reddy R. Exchange rates of creatine kinase metabolites: feasibility of imaging creatine by chemical exchange saturation transfer MRI. NMR Biomed. 2012. 25(11):1305-9.
• Cai K, Shore A, Singh A, Haris M, Hiraki T, Waghray P, Reddy D, Greenberg JH, Reddy R. Blood Oxygen Level Dependent Angiography (BOLDangio) and Its Potential Applications in Cancer Research. NMR Biomed. 2012; 25(10): 1125-32.
• Singh A, Haris M, Cai K, Babu V, Hariharan H, Reddy R. Chemical exchange saturation transfer magnetic resonance imaging of human knee cartilage at 3 T and 7 T. Magn Reson Med. 2012; 68(2):588-94.
• Cai K, Kiefer G, Caruthers SD, Wickline SA, Lanza GM, Winter PM. Quantification of water exchange kinetics for targeted PARACEST perfluorocarbon nanoparticles. NMR Biomed. 2012; 25(2):279-85.
• Haris M, Cai K, Singh A, Hariharan H, Reddy R. In vivo mapping of brain myo-inositol. Neuroimage. 2011; 54: 2079-85.
• Haris M, Singh A, Cai K, McArdle E, Davatzikos C, Trojanowski JQ, Melhem ER, Clark CM, Reddy R, Borthakur A. T1rho (T1r) MR imaging in Alzheimer’ Disease and Parkinson’s Disease with and without Dementia. J Neurology. 2011; 258: 380-5.
• Haris M, Singh A, Cai K, McArdle E, Fenty M, Davatzikos C, Trojanowski JQ, Melhem ER, Clark CM, Borthakur A. T(1?) MRI in Alzheimer’s disease: detection of pathological changes in medial temporal lobe. J Neuroimaging. 2011; 21(2):e86-90.
• Cai K, Caruthers SD, Huang W, Williams TA, Zhang H, Wickline SA, Lanza GM, and Winter PM. MR molecular imaging of aortic angiogenesis. JACC Cardiovasc Imagingn 2010; 3:824-832.
• Winter PM, Cai K, Caruthers SD, Wickline SA, Lanza GM. Emerging nanomedicine opportunities with perfluorocarbon nanoparticles. Expert Rev Med Devices. 2007; 4(2):137-45.
• Winter PM, Cai K, Chen J, Caruthers SD, Wickline SA, Lanza GM. Targeted PARACEST nanoparticle contrast agent for the detection of fibrin. Magn Reson Med 2006; 56:1384-8.

Specialty: Magnetic Resonance Imaging

Fellowship: Postdoctrol Fellow, University of Pennsylvania