Ling Qi, PhD, University of Virginia
Unlocking the Secrecy of Mammalian ER-associated Degradation: One Mouse and Human at a Time
April 26, 2024
11:00 AM - 12:00 PM
Host: Yuwei Jiang, PhD
The Qi laboratory at the University of Virginia (UVA) focused on understanding the complex world of protein degradation in a cellular structure known as the endoplasmic reticulum (ER). His laboratory investigates how the ER maintains its health and balance and how this process, particularly a mechanism called ER-associated degradation (ERAD), is linked to human diseases. Over the years, his laboratory has made significant strides in understanding ERAD in health and disease. One of the most notable achievements is the recent identification of mutations in the critical ERAD pathway involving SEL1L-HRD1 in a group of patients known as ENDI patients, with neurological disorders with onset in infancy. This discovery has enhanced our understanding of how ERAD is linked to specific human conditions, opening up new avenues for research and potential therapies.
Date posted
Feb 12, 2024
Date updated
Apr 16, 2024
Speakers
