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Paisansathan Laboratory

Chanannait Paisansathan, M.D. (Associate Professor, Anesthesiology) is fellowship trained in Neurosurgical, Pediatric and Cardiac anesthesiology. She is the Director of Medical Education for medical students rotating through Anesthesiology. Dr. Paisansathan has helped develop a novel mouse model of subarachanoid hemorrhage (SAH) in order to study the effects of neuro-inflammation and vascular dysfunction on SAH-associated brain injury.

Delayed vasospasm is a common complication following subarachanoid hemorrhage it is a leading cause of morbidity and mortality. The underlying pathogenesis of vasospasms and cerebral vascular dysfunction remains unresolved; increasing evidence suggests that inflammation plays a critical role and likely involves increased leukocyte trafficking. Evidence from Dr. Paisansathan research points to an early release of astrocyte-derived inflammatory protein S100B into cerebrospinal fluid following SAH.  S100B, is a key ligand for the receptor for advanced glycation end-products (RAGE), and is postulated to activate pro-inflammatory pathway(s), which promote cerebrovascular dysfunction. SAH studies are performed on mice using the cranial window preparation, and utilize behavioral studies and molecular analysis of brain and vascular tissue to understand the process of vasospasm.

Dr. Changyaleket, M.D. Ph.D. (Assistant Professor, Anesthesiology) completed a Neuro-anesthesia fellowship and is working with Drs. Minshall and Paisanathan to characterize the relationship between cerebral vascular nitric oxide and caveolin-1 in brain endothelial barrier properties.