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Photo of Tai, Leon

Leon Tai, PhD

Associate Professor

Co-Director, Alzheimer's Disease and Related Dementia Training Program

Department of Anatomy and Cell Biology

Contact

Building & Room:

CME 567B

Office Phone:

312-996-2296

Lab

Building & Room:

CME 660

Related Sites:

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Identify and therapeutically target mechanistic pathways that underlie barrier and neuronal dysfunction in aging and neurodegenerative disorders.

About

Throughout the human body there are specialized, dynamic and complex cellular barrier interfaces that play a central role in tissue and neuronal homeostasis. The cerebrovasculature (CV) is the largest interface of blood to brain contact, and every neuron is supplied by its own capillary. Dynamic processes at the CV prevent the uptake of unwanted molecules from the blood, remove waste products from the brain and supply essential nutrients and signaling molecules to the brain. Our goal is to identify and therapeutically target mechanistic pathways that underlie barrier and neuronal dysfunction in aging and neurodegenerative disorders including Alzheimer's disease, ALS and metabolic dysfunction.