Richard D Minshall, PhD
Professor
Mentor, Biological Mechanisms
Department of Pharmacology and Regenerative Medicine
Contact
Building & Room:
MSB E102
Office Phone:
Email:
About
Dr. Minshall's research program focuses on understanding how structural and scaffolding functions of the endothelial protein caveolin-1 regulate formation and trafficking dynamics of caveolae, cell-cell communication, PMN adhesion and transmigration, and endothelial and epithelial cell proliferation and differentiation during inflammatory injury and repair/remodeling. He is also investigating G protein dependent signaling mechanisms in endothelial cells that regulate von Willbrand factor secretion associated with microvascular thrombosis and multi-organ system failure in sepsis. Using genetic in vivo and in vitro approaches, disease models, and human tissues, his lab is assessing the mechanisms by which caveolin-1 expression level and post-translational modification regulates vascular homeostasis in health and in pathology.