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Photo of Minshall, Richard D

Richard D Minshall, PhD

Professor

Mentor, Biological Mechanisms

Department of Pharmacology and Regenerative Medicine

Contact

Building & Room:

MSB E102

Office Phone:

312-996-1655

About

Dr. Minshall's research program focuses on understanding how structural and scaffolding functions of the endothelial protein caveolin-1 regulate formation and trafficking dynamics of caveolae, cell-cell communication, PMN adhesion and transmigration, and endothelial and epithelial cell proliferation and differentiation during inflammatory injury and repair/remodeling. He is also investigating G protein dependent signaling mechanisms in endothelial cells that regulate von Willbrand factor secretion associated with microvascular thrombosis and multi-organ system failure in sepsis. Using genetic in vivo and in vitro approaches, disease models, and human tissues, his lab is assessing the mechanisms by which caveolin-1 expression level and post-translational modification regulates vascular homeostasis in health and in pathology.