Dieter Klatt, PhD
Associate Professor
Mentor, Biophysics, Bioinformatics and Computational Science
Department of Biomedical Engineering
Contact
Building & Room:
110B NMRL
Office Phone:
Email:
About
The Klatt lab focuses on the refinement and application of elasticity-based diagnostic imaging techniques using MRI. Magnetic Resonance Elastography (MRE) is capable of measuring diagnostically relevant tissue stiffness non-invasively. Recent studies indicate that in Alzheimer's disease and related neurodegenerative diseases, the loss of functional connectivity involves a loss of mechanical connectivity, which can be measured using MRE. The Klatt Lab has improved accuracy and acquisition speed of MRE elastograms by engineering alternative motion encoding concepts that are capable of simultaneously acquiring multidirectional, multifrequency displacement data. Currently sensitivity and effectiveness of MRE measurements in mouse models of Alzheimer's disease, are being assessed by a comparative analysis of disease progression.