Beata M Wolska, PhD
Professor
Mentor, Vascular Therapeutics
Department of Physiology and Biophysics
Department of Medicine, Cardiology
Contact
Building & Room:
CSB 1112
Office Phone:
Fax:
Email:
Related Sites:
Interests Heading link
My laboratory is interested in the integrated control of membrane and myofilament-related mechanisms regulating cardiac function in physiological and pathological conditions. We focus on the development of new treatments for HCM and DCM.
About
My laboratory is interested in the integrated control of membrane and myofilament related mechanisms regulating cardiac function in physiological and pathological conditions. We focus both on the role of Ca2+ delivery to and from myofilaments and the myofilament response to Ca2+, and how they interact and alter each other. Our recent work in animal models has provided evidence indicating the HCM phenotype can be rescued through modifications at the level of the myofilaments or through alterations promoting Ca2+ homeostasis by targeting Ca2+-handling proteins. We have published the proof of concept studies that early interventions in bringing myofilaments Ca2+ sensitivity close to normal level is critical for rescuing HCM and DCM. Our recent data indicates that an important mechanism in this rescue also involves the vascular system. Our long-term goal is to develop individual-based specific treatments for HCM and DCM that could potentially replace or modify current therapies.