Beata M Wolska, PhD
Professor
Department of Physiology and Biophysics
Department of Medicine, Cardiology
Contact
Building & Room:
CSB 1112
Office Phone:
Fax:
Email:
Related Sites:
About Heading link
Dr. Wolska’s laboratory is interested in the integrated control of membrane and myofilament-related mechanisms regulating cardiac function in physiological and pathological conditions. They focus on the role of Ca2+ delivery to and from myofilaments, the myofilament response to Ca2+, and how they interact and alter each other. Recent work in animal models has provided evidence indicating the HCM phenotype can be rescued through modifications at the level of the myofilaments or through alterations promoting Ca2+ homeostasis by targeting Ca2+-handling proteins. The Wolska Lab have published proof-of-concept studies showing that early interventions in bringing myofilaments Ca2+ sensitivity close to normal levels are critical for rescuing dilated and hypertrophic cardiomyopathies. Recent data indicates that early changes in the vascular system are also important in cardiomyopathies. Their goal is to develop individual-based specific treatments for genetically linked cardiomyopathies that could potentially replace or modify current therapies.