R John Solaro, PhD
Distinguished University Professor
Department of Physiology and Biophysics
Contact
Building & Room:
COMRB 2055
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Fax:
Lab
Building & Room:
COMRB 2088
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Integration of molecular, chemical, and mechanical signaling to and from cardiac myocytes with physiology, pathology, and pharmacology at the level of the heart and organism.
About
We want to develop therapies for acquired and familial cardiac disorders. A current emphassi of our experiments is on Hypertrophic cardiomyopathy (HCM) and Dilated Cardiomyopathy (DCM) are common familial cardiovascular disorders linked to variants in genes encoding proteins of the cardiac sarcomere. There are no cures. Despite decades of basic and clinical research, there are critical gaps in our knowledge concerning how defective biophysical signals in the myocyte influence the function of other cellular compartments of the heart during the clinical course of this disorder. Our experiments employ discovery proteomics and transcriptomics to uncover new mechanisms and possible targets for diagnosis and therapy. The findings are correlated with cardiac and vascular function at various levels of organization, histology, and effects of current and new potential therapies.