Sejeong Shin, PhD
Research Assistant Professor
Department of Physiology and Biophysics
Contact
Building & Room:
COMRB 5060
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About Heading link
Dr. Shin earned her Ph.D. in Structural Biology from the Pohang University of Science and Technology (POSTECH) in South Korea, focusing on protein structure and structure-function relationships using X-ray crystallography. As a postdoctoral fellow at Harvard Medical School, she focused her research on the RAS/ERK, TGF-beta, and PI3K/AKT signaling pathways, particularly studying their roles in epithelial-mesenchymal transition (EMT) during cancer progression. Since joining the University of Illinois College of Medicine in 2016, her research has expanded to include the mTOR, PI3K/AKT, RAS/ERK, and TGF-beta pathways to advance cancer treatment strategies.
Research/Teaching Heading link
Dr. Shin’s research focuses on understanding the mTOR, PI3K/AKT, RAS/ERK, and TGF-beta signaling pathways to uncover therapeutic strategies for cancer. Her work explores the mechanisms of EMT, the mTOR feedback loop, and drug resistance to targeted therapies, with the goal of advancing effective cancer treatments.
Selected Publications
Shin S, Han MJ, Jedrychowski MP, Zhang Z, Shokat KM, Plas DR, Dephoure N, Yoon SO. (2023) mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching. Cell Reports, 42, 112868
Shin S, Buel GR, Nagiec MJ, Han MJ, Roux PP, Blenis J, and Yoon SO (2019). ERK2 regulates epithelial to mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation. Proc Natl Acad Sci USA. 116, 2967-2976
Yoon SO*, Shin S*, Karreth FA, Buel GR, Jedrychowski MP, Plas DR, Dedhar S, Gygi SP, Roux PP Dephoure N, Blenis J. (2017) Focal adhesion- and IGF1R-dependent survival and migratory pathways mediate tumor resistance to mTORC1/2 inhibition. Mol Cell, 67, 512-527 *co-first author
Shin S, Buel GR, Wolgamott L, Plas DR, Asara JM, Blenis J, Yoon SO (2015). ERK2 mediates metabolic stress response to regulate cell fate. Mol Cell, 59, 382-398
Shin S, Dimitri CA, Yoon SO, Dowdle W, and Blenis J. (2010) ERK2, but not ERK1, induces epithelial to mesenchymal transformation via DEF motif-dependent signaling events. Mol Cell 38, 114-127