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Photo of Nadeem, Taliha

Taliha Nadeem, PhD

VBST Postdoctoral Fellow

Department of Physiology and Biophysics


Building & Room:

COMRB 2168

Office Phone:


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Jan Kitajewski, PhD

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Mentors: Jan Kitajewski, PhD and Andrius Kazlauskas, PhD 

Pathological neovascularization is a critical step in the progression of ocular pathologies such as retinopathy of prematurity and diabetic retinopathy. Neovascular retinopathies are driven by increased levels of inflammatory cytokines. We have previously demonstrated that Notch1 and Notch4 signaling regulate the production of CC-chemokines in cultured human umbilical vascular endothelial cells. This suggests that blocking Notch1 and Notch4 signaling may reduce endothelial inflammation and subsequently limit pathological neovascularization. My goal is to characterize Notch1 and Notch4 function in retinopathy of prematurity/oxygen-induced retinopathy (OIR) models using genetically modified mice to understand the contributions of endothelial Notch signaling to the progression of ocular pathologies. Through this work, I hope to also provide insight into endothelial-Notch signaling induced microglial chemoattraction and how it may affect neovascularization.