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Photo of Liew, Chong Wee

Chong Wee Liew, PhD

Associate Professor

Department of Physiology and Biophysics

Contact

Building & Room:

COMRB 2099

Office Phone:

312-413-1086

Lab

Building & Room:

COMRB 2120

About Heading link

Chong Wee Liew is an Associate Professor in the Department of Physiology and Biophysics at the University of Illinois Chicago. He is also an adjunct Associate Professor of the Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, and a Fellow of the UIC Honors College.

Chong Wee received his B.Sc., B.Sc. (Hons) and M.Sc. in Microbiology from National University of Singapore, and a Ph.D. in Cell Biology from University of Hamburg, Germany. After that, Chong Wee moved to Boston, Massachusetts to do his postdoctoral training in the laboratory of Dr. Rohit N. Kulkarni at the Joslin Diabetes Center, Harvard Medical School. Based on his pioneering work on a transcription co-regulator, TRIP-Br2, Chong Wee was awarded the NIH K99/R00 Pathway to Independence Award by NIDDK and was subsequently promoted to become Research Associate at the Joslin Diabetes Center and Instructor of Medicine at the Harvard Medical School.

Chong Wee has published over 60 peer-reviewed publications. He has received research funding from federal agencies and foundations. Chong Wee also serves on editorial board of journals and on NIH and regional grant review committees

Research/Teaching Heading link

Research interests: Adipose tissues (white, brown and beige) are constantly being remodeled to adapt to metabolic needs and environmental challenges. In response to a variety of hormonal, nutritional (e.g. fasting, overacting), environmental (cold exposure) cues, adipose tissues will undergo metabolic adaptation involving lipolysis, lipogenesis, adipogenesis, mitochondria biogenesis/clearance, and thermogenesis to regulate whole-body metabolic and energy homeostasis. Using cutting-edge technologies and multidisciplinary approaches (e.g. molecular biology, biochemistry, genetics, bioinformatics), Dr. Liew aims to understand/identify regulatory mechanisms modulated during physiological and patho-physiological perturbations. His long-term goal is to use these insights to contribute to new therapeutic strategies for the treatment of metabolic diseases (obesity, diabetes).

Teaching contribution: Dr. Liew teaches lectures in the Master of Science in Medical Physiology and in the first- and second-year courses of the Graduate Education in Biomedical Sciences (GEMS) Program. Dr. Liew is also the Director for PHYB531 (Integrative Metabolism) and PHYB572 (Clinical Application of Physiology) graduate courses.

Selected Publications

Wang X, Li Y, Qiang G, Wang K., Dai J, McCann M, Munoz MD, Gil V, Yu Y, Li S, Yang Z, Xu S, Cordoba-Chacon J, DeJesus D, Sun B, Chen K, Liu X, Miao Q, Zhou L, Hu R, Ding Q, Kulkarni RN, Gao D, Bluher M, Liew CW. Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity. Nature Commun. 2022: 13: 7323. PMID: 36443308

Munoz MD, Zamudio A, McCann M, Gil V, Xu P, Liew CW. Activation of brown adipose tissue by a low-protein diet ameliorates hyperglycemia in a diabetic lipodystrophy mouse model. Sci Rep. 2023: 13: 11808. PMID: 37479751

Qiang GF, Whang Kong H, Fang DF, McCann M, Yang XY, Du GH, Bluher M, Zhu JF, Liew CW. The obesity-induced transcription regulator TRIP-Br2 mediates visceral fat ER stress-induced metabolic dysfunction. Nature Commun. 2016: 7: 11378. PMCID: PMC4848483

Qiang GF, Whang Kong H, Xu S, Pham HA, Parlee SD, Burr AA, Gil V, Pang JB, Hughes A, Gu XJ, Fantuzzi G, MacDougald OA, Liew CW. Lipodystrophy and severe metabolic dysfunction in mice with adipose tissue-specific insulin receptor ablation. Mol Metab. 2016: 5: 480-490. PMCID: PMC4921803

Cai Z, Zhong Q, Feng Y, Wang Q, Zhang Z, Wei C, Yin Z, Liang C, Liew CW, Kazak L, Cypess AM,
Liu Z, Cai K. Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging. Nat Metab. 2024 Jul;6(7):1367-1379. doi: 10.1038/s42255-024-01082-z. Epub 2024 Jul 25. PMID: 39054361