Monica Y Lee, PhD
Assistant Professor
Department of Physiology and Biophysics
Contact
Building & Room:
COMRB 2135
Office Phone:
Fax:
Lab
Building & Room:
COMRB 1128
Email:
Related Sites:
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The Lee Lab investigates how endothelial impairment and PI3K/Akt dysregulation triggers the onset of cardiovascular disease. We are currently focused on how endothelial Akt1 activity influences atherosclerotic disease progression.
Service to Community
The Lee Lab utilizes a combination of high-content screening together with modern in vitro and in vivo techniques to strategically investigative how modulation of endothelial Akt1 activity affects downstream functions in relation to vascular development and remodeling. We are currently focused on how endothelial Akt1 activity influences atherosclerotic disease progression with additional interest in novel downstream effectors of Akt. Detailed examination of novel Akt-substrate relationships together with endothelial-targeted Akt1 mouse models promotes a multi-tier approach toward the discovery of novel endothelial biology. Our long-term goals are to: I) uncover the role of endothelial Akt activity in vessel physiology, and to II) investigate novel Akt-substrate relationships to unravel the complexity of Akt signaling and its influence on cardiovascular disease progression. We are a highly collaborative, enthusiastic team of scientists driven by scientific curiosity and a quest for knowledge. We aim to discover new biological processes to contribute to our overall understanding of human health and disease.