Jian-Ping Jin, MD, PhD
Professor
Mentor, Vascular Therapeutics
Department of Physiology and Biophysics
Contact
Building & Room:
CMWT 551
Office Phone:
Fax:
Lab
Building & Room:
MSB 518
Email:
Related Sites:
Interests Heading link
Structure-function relationship of myofilament and cytoskeleton proteins in muscle contractility, cell motility and cardiovascular physiology and pathophysiology.
About
Established in 1993, the Jin lab is interested in the regulation and structure-function relationships of contractile and cytoskeleton proteins. Muscle (cardiac, skeletal and smooth) contraction and non-muscle cell motility play vital roles in physiological activities and pathophysiological adaptations. Our research is focused on actin thin filament-associated regulatory proteins: troponin and calponin, to study their regulation and structure-function relationships. Molecular biology and genetic approaches are used to investigate protein isoform evolution and expression as well as to provide engineered protein and peptide constructs for functional characterization. Biochemical, biophysical and immunochemical methods are used to study protein structure and function. Cell culture systems and transgenic/gene knock-out/knock-in mouse models are developed for integrative functional characterizations at cellular, organ and whole animal levels.