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Photo of Jiang, Yuwei

Yuwei Jiang, PhD

Associate Professor

Department of Physiology and Biophysics

Contact

Building & Room:

COMRB 1097

Office Phone:

312-413-7261

Lab

Building & Room:

COMRB 1120

About Heading link

Dr. Jiang is originally from China and received her BS degree in Biological Sciences from Fudan University, China. She was awarded her PhD degree in Molecular and Human Genetics from Baylor College of Medicine where she focused on organ development, disease modeling and gene regulations. She then moved to the University of Texas Southwestern Medical Center as a Postdoctoral Fellow in the Department of Developmental Biology and the Division of Endocrinology. Dr. Jiang started at UIC as an assistant professor in the Department of Physiology and Biophysics in August 2018. Her current research focuses on the roles of adipose stem cells in adipose tissue development, expansion, and aging.

Research Heading link

How cells and tissues develop and grow, and how these processes go awry in disease states are important questions in biology. The Jiang lab has broad interests to study tissue development and disease, with particular focus on adipose tissues. Using unique genetic mouse models, molecular and cellular biology, and systematic approaches, we aim to understand how fat cells are born, live, function and turn over, and what makes fat cells dysfunctional. By gaining insight into these processes, we hope to translate this knowledge into a cure for obesity and metabolic diseases, to explore and engineer fat into therapeutic opportunities for human health.

Selected Publications

Yuan Y*, Hu R*, Park J*, Xiong S, Wang Z, Qian Y, Shi Z, Wu R, Han Z, Ong SG, Lin S, Varady KA, Xu P, Berry DC, Shu G, Jiang Y#. Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure. Sci Adv. 2024;10(26):eadn5229. Epub 20240626. doi: 10.1126/sciadv.adn5229. PubMed PMID: 38924414

Park J*, Hu R*, Qian Y, Xiong S, El-Sabbagh AS, Ibrahim M, Wang J, Xu Z, Chen Z, Song Q, Song Z, Yan G, Mahmoud AM, He Y, Layden BT, Chen J, Ong SG#, Xu P#, Jiang Y#. Estrogen counteracts age-related decline in beige adipogenesis through the NAMPT-regulated ER stress response. Nat Aging. 2024;4(6):839-53. Epub 20240610. doi: 10.1038/s43587-024-00633-z. PubMed PMID: 38858606

Shi Z, Xiong S, Hu R, Wang Z, Park J, Qian Y, Wang J, Bhalla P, Velupally N, Song Q, Song Z, Jeon MS, Zhang KK, Xie L, Layden BT, Ong SG, Jiang Y#. The Notch-PDGFRbeta axis suppresses brown adipocyte progenitor differentiation in early post-natal mice. Dev Cell. 2024. Epub 20240326. doi: 10.1016/j.devcel.2024.03.012. PubMed PMID: 38569546

Wu R*, Park J*, Qian Y, Shi Z, Hu R, Yuan Y, Xiong S, Wang Z, Yan G, Ong SG, Song Q, Song Z, Mahmoud AM, Xu P, He C, Arpke RW, Kyba M, Shu G, Jiang Q, Jiang Y#. Genetically prolonged beige fat in male mice confers long-lasting metabolic health. Nat Commun. 2023;14(1):2731. Epub 20230512. doi: 10.1038/s41467-023-38471-z. PubMed PMID: 37169793; PMCID: PMC10175245

Park J, Shin S, Liu L, Jahan I, Ong SG, Xu P, Berry DC, Jiang Y#. Progenitor-like characteristics in a subgroup of UCP1+ cells within white adipose tissue. Dev Cell. 2021;56(7):985-99 e4. Epub 2021/03/13. doi: 10.1016/j.devcel.2021.02.018. PubMed PMID: 33711247; PMCID: PMC8026751