Ekrem Emrah Er, PhD
Assistant Professor
Department of Physiology and Biophysics
Contact
Building & Room:
COMRB 1115
Office Phone:
Fax:
Lab
Building & Room:
COMRB 1148
Email:
Related Sites:
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Our lab focuses on understanding how mechanochemical signal transduction (mechanotransduction) within the tumor microenvironment impacts the interactions between cancer cells, vascular stromal cells and immunity during the outgrowth of lethal metastases.
About
Our lab focuses on understanding how mechanotransduction, specifically activation of YAP/TAZ and MRTFA/B transcriptional programs within the tumor microenvironment impacts the interactions between cancer cells, vascular stromal cells and immunity during the outgrowth of lethal metastases. We employ sophisticated ex vivo organotropic models, 2D and 3D multi-cellular in vitro systems, immuno-competent mouse models of metastatic colonization and utilize real-time confocal imaging, patient samples, atomic force microscopy, and bioinformatics. Our goal is to gain new mechanistic insights into cancer metastasis in order to identify novel points of therapeutic intervention, biomarkers of patient survival and therapy response.