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Photo of Er, Ekrem Emrah

Ekrem Emrah Er, PhD

Assistant Professor

Department of Physiology and Biophysics

Contact

Building & Room:

COMRB 1115

Office Phone:

312-355-8070

Lab

Building & Room:

COMRB 1140

Email:

eer@uic.edu

About Heading link

Our lab focuses on understanding how mechanotransduction, specifically activation of YAP/TAZ and MRTFA/B transcriptional programs within the tumor microenvironment impacts the interactions between cancer cells, vascular stromal cells and immunity during the outgrowth of lethal metastases. We employ sophisticated ex vivo organotropic models, 2D and 3D multi-cellular in vitro systems, immuno-competent mouse models of metastatic colonization and utilize real-time confocal imaging, patient samples, atomic force microscopy, and bioinformatics. Our goal is to gain new mechanistic insights into cancer metastasis in order to identify novel points of therapeutic intervention, biomarkers of patient survival and therapy response.