Jonathan Coloff, PhD
Associate Professor
Department of Physiology and Biophysics
Contact
Building & Room:
COMRB 2091
Office Phone:
Fax:
Lab
Building & Room:
COMRB 2100
Email:
Related Sites:
About Heading link
Dr. Coloff grew up in Iowa and graduated from Iowa State University with a BS in Biology. He received his PhD from Duke University where he studied connections between metabolism and cell death in Dr. Jeff Rathmell’s lab. He completed his postdoctoral work in Dr. Joan Brugge’s lab at Harvard Medical School where he studied tumor metabolism. Dr. Coloff then started his lab at UIC in 2018.
Research Heading link
The Coloff Lab investigates the metabolic changes associated with cancer, with the ultimate goal of developing strategies of targeting metabolism for cancer therapy. Current work focuses on identifying lineage-specific metabolic vulnerabilities in breast cancer and understanding how nutrient availability can impact the response to therapeutic agents.
Selected Publications
Conger KO, Chidley C, Ozgurses ME, Zhao H, Kim Y, Semina SE, Burns PA, Rawat V, Lituvninkas L, Sheldon RD, Ben-Sahra I, Frasor J, Sorger PK, DeNicola GM, Coloff JL. (2024) ASCT2 is a major contributor to serine uptake in cancer cells. Cell Reports. Aug 27;43(8):114552
Rawat V, DeLear P, Prashanth P, Ozgurses ME, Tebeje A, Burns PA, Conger KO, Solis C, Hasnain Y, Novikova A, Endress JE, Gonzalez-Sanchez P, Dong W, Stephanopoulos G, Rathmell WK, DeNicola GM, Harris IS, Sept D, Mason FM, Coloff JL. (2024) Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy. JCI Insight. May 30:e174329
Choi BH, Rawat V, Hogstrom J, Burns PA, Conger KO, Ozgurses ME, Patel JM, Mehta TS, Warren A, Selfors LM, Muranen T, Coloff JL. (2022) Lineage-Specific Silencing of PSAT1 Induces Serine Auxotrophy and Sensitivity to Dietary Serine Starvation in Luminal Breast Tumors. Cell Reports. 38(3):110278
Choi BH, Coloff JL. (2019) The diverse functions of non-essential amino acids in cancer. Cancers. May 15;11(5). pii: E675