Tung Nguyen – Thesis Defense – University of Illinois at Chicago
June 14, 2024
11:00 AM - 12:00 PM
As the innermost lining of blood vessels, endothelial cell (EC) health is increasingly recognized as a critical factor in preventing age-related processes. Recent studies report increased nuclear leakiness with aging, highlighting the importance of proper nucleocytoplasmic transport for cellular health. As the major regulator of molecular transport across the nuclear envelope, the nuclear pore complex (NPC) in ECs may also be compromised with age to drive vascular disease. Our recent findings demonstrate that Nucleoporin93 (Nup93), a key NPC protein, is necessary for endothelial nuclear integrity, where loss of Nup93 promotes nuclear Yap enrichment for consequent EC senescence. Moreover, we implicate Nup93 as a novel regulator of endothelial cytoskeletal remodeling by preventing aberrant RhoA activity, contributing to the growing importance of nuclear envelope components in EC and vascular biology.
Host: Monica Lee, PhD
Date posted
May 9, 2024
Date updated
Jun 10, 2024
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