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Jun 14 2024

Tung Nguyen – Thesis Defense – University of Illinois at Chicago

June 14, 2024

11:00 AM - 12:00 PM


1020 COMRB, Moss Auditorium


As the innermost lining of blood vessels, endothelial cell (EC) health is increasingly recognized as a critical factor in preventing age-related processes. Recent studies report increased nuclear leakiness with aging, highlighting the importance of proper nucleocytoplasmic transport for cellular health. As the major regulator of molecular transport across the nuclear envelope, the nuclear pore complex (NPC) in ECs may also be compromised with age to drive vascular disease. Our recent findings demonstrate that Nucleoporin93 (Nup93), a key NPC protein, is necessary for endothelial nuclear integrity, where loss of Nup93 promotes nuclear Yap enrichment for consequent EC senescence. Moreover, we implicate Nup93 as a novel regulator of endothelial cytoskeletal remodeling by preventing aberrant RhoA activity, contributing to the growing importance of nuclear envelope components in EC and vascular biology.

Host: Monica Lee, PhD


Edgar Solis

Date posted

May 9, 2024

Date updated

Jun 10, 2024


Tung Nguyen | PhD Candidate | UIC