Simon Schwörer, PhD – University of Chicago
November 22, 2024
11:00 AM - 12:00 PM
Location
1020 COMRB, Moss Auditorium
Calendar
Download iCal FileHost: Alexandra Naba, PhD
"Tumor Metabolites Regulate Fibroblast State and Function to Drive Inflammation and Matrix Production in Pancreatic Cancer"
The Schwӧrer lab seeks to understand how nutrient availability and utilization regulate cell plasticity and function. Towards this goal, the lab uses fibroblasts as a model, which can acquire different states in response to environmental cues and have a unique function (i.e., extracellular matrix (ECM) production). The lab specifically focuses on cancer-associated fibroblasts (CAFs) in pancreatic cancer, an aggressive tumor with abundant desmoplastic stroma and substantially altered nutrient availability. I will discuss our recent findings on how CAF state and function is shaped by the metabolites available to them, and how this in turn alters inflammation and the ECM to regulate pancreatic cancer cell biology.
Date posted
Jun 27, 2024
Date updated
Nov 18, 2024
Speakers
