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May 10 2024

Meenal Datta, PhD, University of Notre Dame

Immunomechanics in Glioblastoma

May 10, 2024

11:00 AM - 12:00 PM


1020 COMRB, Moss Auditorium


Host: Emrah Er, PhD

Here, I will discuss our engineering-based approaches for exploring “immunomechanics” (i.e., the generation of physical forces by immune cells) and “mechano-immunology” (i.e., the impact of physical forces on immune cell function) in the context of glioblastoma– a rare but universally fatal brain cancer. The glioblastoma microenvironment is comprised up to 50% by innate immune cells, such as macrophages. We posit that tumor-supporting macrophages are reciprocally regulated with mechanical forces in the tumor microenvironment, fueling cancer progression and treatment resistance. Our new 3-D model allows us to study these interactions and reveal targetable mechanisms to improve therapeutic response, not only in the context of glioblastoma, but other cancers and diseases as well.


Edgar Solis

Date posted

Apr 1, 2024

Date updated

Apr 16, 2024


Meenal Datta | PhD | University of Notre Dame