Meenal Datta, PhD, University of Notre Dame
Immunomechanics in Glioblastoma
May 10, 2024
11:00 AM - 12:00 PM
Host: Emrah Er, PhD
Here, I will discuss our engineering-based approaches for exploring “immunomechanics” (i.e., the generation of physical forces by immune cells) and “mechano-immunology” (i.e., the impact of physical forces on immune cell function) in the context of glioblastoma– a rare but universally fatal brain cancer. The glioblastoma microenvironment is comprised up to 50% by innate immune cells, such as macrophages. We posit that tumor-supporting macrophages are reciprocally regulated with mechanical forces in the tumor microenvironment, fueling cancer progression and treatment resistance. Our new 3-D model allows us to study these interactions and reveal targetable mechanisms to improve therapeutic response, not only in the context of glioblastoma, but other cancers and diseases as well.
Date posted
Apr 1, 2024
Date updated
Apr 16, 2024
Speakers
