Seminar – Sunny Shin, PhD – Innate immune defense against intracellular bacterial pathogens
University of Pennsylvania Perelman School of Medicine
March 25, 2024
12:00 PM - 1:00 PM
Location
1020 COMRB
Calendar
Download iCal FileIntracellular pathogens pose a unique set of challenges for the immune system. While eukaryotic organisms possess evolutionarily conserved innate immune sensors and signaling pathways to sense and respond to infection, intracellular pathogens likewise possess evolutionarily conserved mechanisms to disrupt, evade, or modulate cellular signaling networks. Thus, while the mechanisms of PRR activation by isolated PAMPs are reasonably well-understood, how the immune system successfully generates responses against pathogens that utilize virulence factors to shut off cellular responses is less clear. Many bacterial pathogens deploy virulence factors that disrupt key immune processes, raising the question of how a robust immune response can be generated during bacterial infection. I will discuss our recent findings elucidating how the immune system overcomes bacterial virulence activities in order to generate a robust antimicrobial response.
Date posted
Mar 7, 2024
Date updated
Apr 3, 2024
Speakers
