The University of Illinois at Chicago’s transplant program was established in 1968 and has performed more than 2,000 transplant surgeries of the kidney, liver, kidney-pancreas, pancreas, and small bowel. Our transplant program has achieved the highest rates of patient and graft survival in 2009 for kidney, kidney/pancreas, and liver transplant in Illinois despite a very challenging case mix as documented by the latest official release from UNOS. The University of Illinois Medical Center’s one-year adult patient survival rates were 100 percent for kidney-pancreas transplantation, 98 percent for kidney transplantation, and 89 percent for liver transplantation. The one-year graft survival rates were 100 percent for kidney-pancreas transplantation, 96 percent for kidney transplantation, and 85 percent for liver transplantation. These successful results can be attributed to many factors, and the anesthetic and perioperative management has an important role.