Pulmonary Vascular Biology And Critical Care Research Laboratories

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Pulmonary Vascular Biology And Critical Care Research Laboratories 2017-07-28T09:42:23+00:00

Dull Laboratory

Dr. Dull MD, Ph.D., the Director of Anesthesia Research, studies glycobiology and mechanobiology of the lung and vascular system; his work has identified novel mechanism(s) regulating vascular permeability and the susceptibility of the lung to mechanical forces.  Specifically, Dr. Dull and his collaborators have demonstrated that heparan sulfate proteoglycans are flow and pressure sensors that activate oxidative pathway(s) leading to increased vascular permeability. Increases in capillary pressure activate a heparan sulfate-nitric oxide dependent pathway that leads to increased edema formation. Read more…

Minshall Laboratory

Richard D. Minshall, Ph.D. (Associate Professor, Anesthesiology Pharmacology, Bioengineering) studies the molecular regulation of endothelial permeability pathways and pathological mechanisms of pulmonary hypertension, acute lung injury, and ARDS. In addition, Minshall and colleagues are investigating anti-inflammatory, immunomodulatory, and anti-metastatic effects of volatile and local anesthetics. Red more…

Hu Laboratory

Gouchang Hu, MD, Ph.D. (Assistant Professor, Anesthesiology & Pharmacology) studies sepsis-mediated acute lung injury and regulation of pulmonary alveolar and vascular inflammation via TLR-4 and p-120 catenin. These studies utilize cell culture, isolated lungs and whole animal models of sepsis to determine the role of TLR-4 mediated lung injury. Read more…

Cho Laboratory

Jaehyung (Gus) Cho, Ph.D. (Assistant Professor, Anesthesiology & Pharmacology) studies the molecular mechanisms of the platelet-leukocyte-endothelium interactions at the site of vascular injury. These studies are being performed using pharmacologic and genetic approaches in real-time fluorescence microscopy in vitro and in vivo. Read more…