Cardiovascular Research Laboratory

Cardiovascular Research Laboratory 2017-07-28T09:42:44+00:00

Weinberg Laboratory

Dr. Wienberg is the Department’s most distinguished clinician-scientist and he is internationally recognized for his pioneering work demonstrating the use of lipid emulsion for resuscitation from local anesthetic overdose (www.Lipidrescue.org).
Dr. Weinberg first reported in 1998 that a standard soy-based lipid emulsion, typically used for parenteral nutrition, rapidly reversed the cardiotoxic effects of local anesthetics in rats. He later confirmed this effect in a dog model of bupivacaine overdose and found that lipid emulsion accelerates clearance of bupivacaine from isolated rat hearts. The antidotal effect of lipid infusion has subsequently been confirmed in laboratory models and case reports of local anesthetic toxicity as well as overdoses of other lipophilic drugs including calcium channel blockers, beta blockers and tricyclic antidepressants.
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